Báo cáo y học: "Refined study of the interaction between HIV-1 p6 late domain and ALIX" ppsx

Báo cáo Y học: Biophysical characterization of the interaction of high-density lipoprotein (HDL) with endotoxins doc

... scan reveals only a very small hysteresis for the re-crystallization of the acyl chains from the liquid crystal-line to the gel phase. The maximum of the heat capacitycurve of the 1st cooling ... can dock lipopolysaccharide-binding pro-teins. They are classiﬁed as very-low density, low-densityand high-density lipoproteins (HDL) according to theirbuoyant density. The primary function of ... (Fig. 10). The comparison of the results of the interaction of LPS with HDL to those published for the interaction of the former with another serum protein, albumin, indicates acompletely different...

Báo cáo Y học: Fluorescence study of the high pressure-induced denaturation of skeletal muscle actin pdf

... ressureshown by the arrows.Ó FEBS 2002 Pressure-induced denaturation of actin (Eur. J. Biochem. 269) 369 Fluorescence study of the high pressure-induced denaturation of skeletal muscle actin Yoshihide ... Biochemistry 5, 1551±1560] made a thorough study of the eect of pressure onG- and F-actins. However, all of the measurements in their study were made after the release of p ressure. In the presentexperiment ... actin molecules ( the decay curve of the intensity o f uorescence of eATP -G -actin or eADPF -actin) followed đrst-orderkinetics. The volume changes for the denaturation of G -actin and F -actin were estimated...

Báo cáo khoa học: Molecular analysis of the interaction between cardosin A and phospholipase Da Identiﬁcation of RGD/KGE sequences as binding motifs for C2 domains pdf

... Taken together our results indicate that the C2 domain of plant phospholipase Da can act as a cardosin A- binding domain and suggest that plant C2 domains may have an additional role as RGD ⁄ KGE-recognition ... of both motifs and in particular their basic residues was fur-ther emphasized by the complete lack of interaction between the C2 domain and the double mutated(AGD ⁄ AGE) cardosin A. The docking ... -trans-ferase-fused phospholipase Da constructs were performed. Results revealedthat the C2 domain of phospholipase Da contains the cardosin A- binding activity. Further assays with mutated recombinant...

Báo cáo y học: "Differential expression of the angiogenic Tie receptor family in arthritic and normal synovial tissue" doc

... play important rolesprincipally during the later stages of angiogenesis. We have compared the distribution of the receptor tyrosine kinase (Tie) and the Ang ligands in synovial tissues from normal ... mRNA and protein levels in RA synovial tissue compared to that from patients with OA and normal subjects. Hypothetically, in RA synovial tissue the dominating Ang-1 induces the Tie2 pathway, whereas in ... al. Tie receptors constitute a family of endothelial tyrosinekinase receptors [3,4]. There are two members in this receptor family, termed Tie1 and Tie2 (also known as Tek). Tie1 is an orphan receptor, ...

Báo cáo y học: "Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues" doc

... original work is properly cited.Abstract The focal adhesion kinase (FAK) family kinases, including FAK and proline-rich kinase 2 (Pyk)2, are the predominant mediators of integrin αvβ3 signaling ... kinase (FAK) and proline-rich tyrosine kinase (Pyk)2 are two members of a family of nonreceptor protein tyrosine kinases that are acti-vated by a variety of extracellular stimuli [1]. FAK and ... with FAK, including paxillin [38]. Overexpression of FAK and PLCγ in COS-7 cells increases PLCγ enzymatic activity and tyrosinephosphorylation. FAK- induced PLCγ phosphorylation may bedue to FAK...

Báo cáo y học: "Phylogenetic detection of numerous gene duplications shared by animals, fungi and plants" ppsx

... d).Discussion Detection of very ancient eukaryotic gene duplications In this study, we investigated the extent of eukaryotic gene duplication before the divergence of plants and animals /fungi by constructing ... y more gene duplicatio nFigure 1 Alternative views of the eukaryotic phylogeny and the design of phylogentic analysis. (a) The ‘crown-stem’ topology of eukaryotic phylogeny. The topology shown ... analysis and dataexploration. Bioinformatics 2008, 24:1650-1651.doi:10.1186/gb-2010-11-4-r38Cite this article as: Zhou et al.: Phylogenetic detection of numerous gene duplications shared by animals,...

Báo cáo y học: "Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture" potx

... assay.Protection of cells from HIV infection after removal of drug from cultureWe investigated the persistence of anti -HIV activity to pro-tect cells from HIV infection after removal of drug ... satisfies the abovecriteria and was able to detect differences in the persist-ence of anti -HIV activity of inhibitors tested.Conclusion The persistence of anti -HIV activity of the inhibitors ... differences in the persistence of anti -HIV activity of the inhibitors stud-ied; our findings are, therefore, a reflection of the differ-ences in the inhibitors. Though, the use of PBMCs forthese studies...

Báo cáo y học: " A study of the effectiveness of telepsychiatrybased culturally sensitive collaborative treatment of depressed Chinese Americans" pptx

... the effectiveness of telepsychiatry-based culturally sensitive collaborative treatment of depressed Chinese AmericansAlbert Yeung*, Kate Hails, Trina Chang, Nhi-Ha Trinh and Maurizio FavaAbstractBackground: ... States. The current study will evaluate the viability of one such approach, telepsychiatry-based Cultu-rally Sensitive Collaborative Treatment, or T-CSCT.Preliminary StudiesMany Chinese Americans, ... evaluate the acceptability and effectiveness of a telepsychiatry-based culturally sensitive collaborative treatment (T-CSCT) intervention targeted toward Chinese Americans. Patients meeting the...

Báo cáo y học: "Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocyte" pot

... increase of metallopro-teases, [35,36] the expression of phospholipase A2 [37,38] and cyclooxygenase-2, [39] and the concentrations of prostaglandin E2 [40]. They also reduce the concentration of ... glycolytic energy production ([15] and ourobservations), it is then lowered by CS (which reducesfive of these enzymes) and by the combination of bothdrugs (which reduces all seven glycolytic ... Boumediene K, Pujol JP: Chondroitin sulfate increases hyaluronan production by human synoviocytes through differential regulation of hyaluronan synthases: Role of p38 and Akt. Arthritis Rheum...

Báo cáo y học: "Refined study of the interaction between HIV-1 p6 late domain and ALIX" ppsx

... partially rebuilds the arm 2 of the V-shape domain and encompasses the great majority of the hydrophobicsurface residues which presumably contact the late domains [17]. Remarkably, the minimal p6 and ... increased affinity of the mutant late domain for ALIX probably by alleviating the bend between N and C terminus of p6. As suggested by invivo analysis, a tightly interaction between late domain inhibited ... of the p6 hingeregion and enable the subsequent binding of the HIV-1 late domain to the ALIX V domain within the 391–510fragment.During the submission of this work the crystal structuresof...

Báo cáo y học: "Using MRI of the optic nerve sheath to detect elevated intracranial pressure" ppsx

... demon-strating the correlation of MRI measurements of the ONSDwith invasive ICP monitoring, they illustrate the potential of yetanother non-invasive method to screen for elevated ICP.While this ... usemeasurements of the ONSD to predict exact values of ICP,but it may be useful as a screening test to estimate the probability of elevated ICP.Competing interests The authors declare that they have ... intrathecal infusion tests. J Neurosurg1997, 87:34-40.9. Blaivas M, Theodoro D, Sierzenski PR: Elevated intracranial pressure detected by bedside emergency ultrasonography of the optic nerve sheath. ...

Báo cáo y học: " Immunohistochemical study of the phenotypic change of the mesenchymal cells during portal tract maturation in normal and fibrous (ductal plate malformation) fetal liver" pot

... mesenchymal cells in the portal tract are not stained(Figure 28).Cytokeratin 19 The staining of the biliary cells depended of the level of maturation. In the beginning, the cells of the ductal platesbegan ... study explored the phenotypic heterogeneity of the mesenchymal cells during liver development, mainlyalong the portal tract tree in normal and in a large series of fibrous fetal liver. For the ... mesenchymal cells during the normal development of the fetal liver and to explore the phenotypic evolution of the portal tract mesenchymal cells during the abnormal development of fetal liver presenting fibrosis...

Báo cáo y học: "Current understanding of the relationship between cervical manipulation and stroke: what does it mean for the chiropractic profession" pps

... 16:10.doi:10.1186/1746-1340-18-22Cite this article as: Murphy: Current understanding of the relationship between cervical manipulation and stroke: what does it mean for the chiropractic profession?. Chiropractic ... individually and as a group.They used seven days as the time period between the mechanical event and stroke for all the potential riskfactors except CMT, for which they used a 30 day cut-off. They ... that they are experiencing VADS.4. However there often can be subtle signs and symptoms that may alert a health provider to the possibility of the presence of VADS5. If you experience any of these...

Báo cáo y học: " Theoretical study of the Usutu virus helicase 3D structure, by means of computer-aided homology modelling" ppsx

... ModellingOpen AccessResearch Theoretical study of the Usutu virus helicase 3D structure, by means of computer-aided homology modellingDimitrios VlachakisAddress: Institute of Biology, National Centre ... representation of the produced Usutu virus helicase model. B: the Usutu virus helicase model superim-posed with its Murray Valley Encephalitis virus helicase template (RCSB entry: 2V80). The Usutu virus helicase ... sup-ported by the analysis of the helicase structures availablefor the whole Flaviviridae family that revealed that the overall 3D structure for the Murray Valley Encephalitis virus helicase ishighly...

Báo cáo y học: "Genomic analysis of the relationship between gene expression variation and DNA polymorphism in Drosophila simulans" pps

... arbitrary and chosen because they resulted in about half of the genes falling into 'average' gene expres-sion and the remainder of the genes falling roughly equallyinto 'high' and ... divergence and expression variation. In addition to discovering genes that vary in expression bygenotype, we also categorized genes based on gene featurelength and levels of expression intensity. Expression ... statistically signif-icantly different among lines and that inclusion of these genes in the analysis may obscure an effect. Thus, we repeated the analysis with the 500 genes with the strongest...

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