... hTK1.In the present work, the part of the phosphatedonor that is necessary for the dimer–tetramer transi-tion of native hTK1 purified from human lymphocyteswas identified. Further, the effect of the ... 10 0– 120 kDa (see Table 1). Therefore, it can be concluded that the nature of the base is insignificant for the tetra-merization effect. The next goal was to determine the role played by the ... adenosine. InTmTK, the adenosine moiety was bound at the a-helix dimer interface, and this form is more openthan hTK1. Therefore, at present, it appears that the adenosine group is very loosely...