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Báo cáo khoa học: "Bench-to-bedside review: The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury" pot

Báo cáo khoa học:

Báo cáo khoa học: "Bench-to-bedside review: The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury" pot

... However, in the ReviewBench -to- bedside review: The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injuryMark R Looney1 and Michael A ... thrombin-thrombomodulincomplex to yield APC, a natural anticoagulant that limitsthrombin production [6]. The epithelial protein C receptor(EPCR) plays a role in accelerating the activation of protein C by binding ... for APC in maintaining the integrity of the endothelium through both direct and indirect mechanisms. APC can potentially limit the elabora-tion of proinflammatory cytokines, such as tumor necrosisfactor-α...
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Báo cáo khoa học: "Clinical review: The meaning of acid–base abnormalities in the intensive care unit – epidemiolog" ppt

... metabolicacidosis on an absolute chloride value rather than to take intoaccount the physicochemical principles of either the decreased ratio of sodium to chloride or the decreaseddifference between ... acids include plasma proteins (predominatelyalbumin) and phosphates. The total charge of these mustequal the SIDa. The product of all of the measurable anionscontributing to the balancing negative ... when acid–basedisorders are evaluated [23,40,79,80].Incidence of metabolic acidosis in the intensive care unit The incidence of metabolic acidosis in the ICU is difficult to extrapolate from the...
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Báo cáo khoa học:

Báo cáo khoa học: "Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis" pot

... (PC), (b) activated protein C (APC), and (c) APC/PC ratio during hospital stay in patients with acute pancreatitisLevels of (a) protein C (PC), (b) activated protein C (APC), and (c) APC/PC ratio ... concentrations of (a) protein C (PC), (b) activated protein C (APC), and (c) APC/PC ratio during the stay in hospital in nine patients with organ failureFollow-up concentrations of (a) protein ... surface [6]. This effect isenhanced by the endothelial PC receptor [7]. APC conveys its anticoagulant function mainly by proteolytic inactivation of coagulation activated factor V and activated...
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Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf

Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf

... sub-unit of the G protein and not in the other case.Although there is discussion in the literature concern-ing the possibilities of photoconversion of YFP into aCFP-like species during acceptor ... indicatedbasic region of ic3 of the D2receptor and acidic region of the C- tail of the D1receptor might be involved in the interactions between the two dopamine receptors. In addition, the ... manipulating the Arg-rich epi-tope in the ic3 of the D2receptor induced alterations in the cellular localization of the resulting receptor pro-teins. If not for confocal microscopy, which allowed...
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Báo cáo khoa học: "Re-evaluating the Role of B LEU in Machine Translation Research" ppt

... adequatebecause it fails to indicated that Kharazi is boy-cotting the conference, and because it inserts the word stood before accused which makes the Ab-dullah’s actions less clear. The second hypothe-sis ... translations of phrases in the Arabic source sentences and post-editing the result(Callison-Burch, 2005). The remaining six entrieswere all fully automatic machine translation sys-tems; in fact, they ... ResearchChris Callison-Burch Miles Osborne Philipp KoehnSchool on InformaticsUniversity of Edinburgh2 Buccleuch PlaceEdinburgh, EH8 9LWcallison-burch@ed.ac.ukAbstractWe argue that the machine...
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Báo cáo khoa học: "Clinical review: The implications of experimental and clinical studies of recruitment maneuvers in acute lung injury" pptx

... regarding clinical use of recruitmentmaneuvers, and the interactions between lung infection and application of high intrathoracic pressures.Keywords acute lung injury, lung collapse, lung infection, ... at 2 cmH2O above the lower inflection pointwas more effective in maintaining gas exchange and minimiz-ing inflammation and lung injury than was PEEP set at the maximum curvature of the deflation ... overdistension and cyclic collapse and reopening of alveoli have successfully been used in patients with ARDSreceiving MV [3,4]. Recruitment maneuvers (RMs) consisting of sustained inflation to open the collapsed...
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Báo cáo khoa học:

Báo cáo khoa học: "Equipment review: The success of early goal-directed therapy for septic shock prompts evaluation of current approaches for monitoring the adequacy of resuscitation" potx

... tract, particularly the stomach, for bothpractical and theoretical reasons. From a practical standpoint, the stomach is already commonly intubated in clinicalpractice for purposes of decompression ... using histaminereceptor antagonists or proton pump inhibitors. The need to use pharmacologic therapy adds to the cost and complexity of the monitoring strategy. Second, enteral feeding can interferewith ... utilizes thistechnology. In the LiDCO system, the reference standardestimation of cardiac output is obtained periodically using the indicator dilution approach by injecting the indicator (a dilutesolution...
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Báo cáo y học:

Báo cáo y học: "Clinical review: The role of the intensive care physician in mass casualty incidents: planning, organisation, and leadership" pot

... command and controlgroups when disaster plans are activated. Anaesthetists receive specific training in incident awarenesswhich extends beyond clinical content, including the non-medical aspects ... regarding the progress of patients who were ultimatelyadmitted to the ICU.ReviewClinical review: The role of the intensive care physician in masscasualty incidents: planning, organisation, and ... bed capacity? (This includes limits in terms of staffing.)Transfer agreements with nearby intensive care units are in place.How do we increase staffing, both clinical and non-clinical, and...
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Báo cáo y học:

Báo cáo y học: "Clinical review: The role of biomarkers in the diagnosis and management of communityacquired pneumonia" potx

... under the ROC curve with 95% con dence intervals. CRP, C- reactive protein; PCT, procalcitonin.Christ-Crain and Opal Critical Care 2010, 14:203 http://ccforum.com/content/14/1/203Page 11 of ... of the adrenals [57]. In a cohort of 373 patients with CAP, copeptin increased with increasing severity of the PSI and was an independent predictor of outcome, in contrast to other clinical ... in CAP will become available as functional genomics and transcriptomics becomes the standard of care in critical care units in the near future. e technology of proteomic profi ling is becoming...
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Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt

Tài liệu Báo cáo khoa học: Insights into the structure of plant a-type phospholipase D Susanne Stumpe, Stephan Konig and Renate Ulbrich-Hofmann ¨ ppt

... to tight packing of the aromatic residues in the core of the protein. From the near-UV CD signals and activity data as a function of the calcium ion concentration, two bind-ing events characterized ... spectroscopic method able to detect speci c binding of calcium ions to PLDa2 (Fig. 4D). The sig-nal increases in this spectrum caused by calcium ionsindicate stiffening of the PLD a2 molecule. ... for the calcium binding [8], we hypothesize that this bind-ing event takes place at the C2 domain.A second calcium-binding site of lower affinity at the C2 domain (corresponding to the dissociationconstant...
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