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Báo cáo khoa học: "Statins, bugs and prophylaxis: intriguing possibilities" pptx

Báo cáo khoa học:

Báo cáo khoa học: "Statins, bugs and prophylaxis: intriguing possibilities" pptx

... care systems and togovernments eager to avoid the potential human and economic consequences of large-scale infection and death.As things stand, the world is ill-prepared for a pandemic.Current ... severalscientific and clinically important questions.Do statins present a potential preventive and/ orsupplementary treatment for seasonal influenza and forthe expected influenza pandemic?Some ... vitro activity of fluvastatin,a cholesterol-lowering agent, and synergy with flucanazole and itraconazole against Candida species and Cryptococcusneoformans. Antimicrob Agents Chemother 1997,...
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Báo cáo khoa học:

Báo cáo khoa học: " Linking Events and Relations to Timestamps" pptx

... events A and B corefer, and thereis a link between A and time expression t, thenthere is also a link between B and t. This was notexplicitly expressed in the data.For the task at hand, we ... systems.Our work is similar to that of Boguraev and Ando (2005), whose research only deals withtemporal links between events and time expres-sions (and does not consider relations at all). Theyemploy ... to both fluents and events, using featureengineering as well as tree kernels. We show thatwe can achieve good results for both events and fluents using the same feature space, and advocate185the...
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Tài liệu Báo cáo khoa học: Affinity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx

Tài liệu Báo cáo khoa học: Affinity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx

... time courses and effects of unlabeled ligands and low pH on the dissociation rates of [125I]TC-PCSK9 (A) and [125I]TC-PCSK9-D374Y (B) from HepG2 cells. Binding to equilibrium and removal of ... HepG2 cells (70 000, 140 000 and 280 000) were seeded in 12-well plates and incubated eitherfor 48 h in complete growth medium or for 24 h in com-plete growth medium, and then for 26 h in 3% LPDS-con-taining ... NaCl ⁄ Picontaining0.1 mm CaCl2 and 0.5% BSA, and three times with 1 mLof wash buffer without BSA. The cells were solubilized in0.5 mL of 0.2 m NaOH, and transferred to counting tubesfollowing...
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Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf

Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf

... PcrH and IpgC are shown in yellow, green and magenta, respec-tively. The peptides located within the concave regions of PcrH and IpgC, corresponding to sections of the N-termini of PopD and IpaB, ... levels (i.e. 38% forPseudomonas PopD and Yersinia YopD; 29% for Shi-gella IpaC and Salmonella SipC). Indeed, sections ofIpaC and SipC (as well as YopD and PopD) are inter-changeable without ... membrane and increasing Salmonella invasionefficiency [62]. It is of note that both IpaC and SipCare essential for Shigella and Salmonella uptake bymacrophages in the early steps of invasion, and...
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx

Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx

... t-bet, stat6 and foxp3 were also determined and found to be very simi-lar to their human homologues. Both the human and zebrafish T-bet and Foxp3 genes contained the samenumber of exons and introns. ... in thelung tissue of mouse and spleen and thymus of human and mouse [11,37]. Foxp3 is also highly expressed inlymphoid organs, such as the thymus and spleen [49], and its expression within a ... zebrafish t-bet, stat6 and foxp3expression was also investigated, and indicated thatthese molecules are biologically relevant to bony fishimmune responses and, in particular, Th and Tregcellresponses....
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Tài liệu Báo cáo khoa học: Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo pptx

Tài liệu Báo cáo khoa học: Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo pptx

... liver and WAT. Paraffinsections of liver and WAT from WT and TGmice (S55) were stained with antibodyagainst human H-PGDS. Bars: 100 lm.(D) PGDS activity in liver of WT and S41,S55 and S66 ... family, and is also called GSTS1[17]. On the other hand, L-PGDS has been purifiedfrom rat brain [18], and is expressed in brain, heart, and male genital organs, as well as in adipocytes and omen-tal ... H-PGDS,hematopoietic prostaglandin D synthase; IBMX, 3-isobutyl-1-methylxanthine; L-PGDS, lipocalin-type prostaglandin D synthase; LPL,lipoprotein lipase; PG, prostaglandin; PGDS, prostaglandin D synthase;...
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Tài liệu Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control ppt

Tài liệu Báo cáo khoa học: Neuropeptide Y and osteoblast differentiation – the balance between the neuro-osteogenic network and local control ppt

... and ubiquitin C-terminal hydrolase (specific markers forneural and neuroendocrine tissues) were found in ratlong bones at embryonic day 15, in the diaphyseal and metaphyseal perichondrium, and ... adrenergic and cholinergic in nature, and originate from paravertebral sympathetic ganglia[16]. Experimental nerve deletion and immunohisto-chemistry analysis have shown that both myelinated and unmyelinated ... thatvary in their binding profiles and in their distributionin the central nervous system and periphery. Y1, Y2 and Y5 are the best characterized NPY receptors, and the majority of NPY functions...
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Tài liệu Báo cáo khoa học: Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase–methionine synthase reductase complex docx

Tài liệu Báo cáo khoa học: Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase–methionine synthase reductase complex docx

... NADPH and MSR 1.12 ± 0.04With NADPH and CPR 0.09 ± 0.02With NADPH and nNOSred 0.18 ± 0.02MeCblWithout MSR or NADPH 0.06 ± 0.01With MSR 1.23 ± 0.15With FMN domain 1.20 ± 0.10With NADPH and ... radioactivity in the flowthrough and wash fractions was quantitated by scintillation counting.For MSR-catalysed assays (used for measuring the KmofNADPH and the Kactof MSR), AqCbl and dithiothreitolwere ... introduced into theglove box, and FeCN was added to the concentrated pro-tein stock to fully oxidize the flavin cofactors. To removeexcess FeCN and O2, MSR and the isolated FMN domainwere...
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Tài liệu Báo cáo khoa học: Molecular cloning and characterization of soybean protein disulfide isomerase family proteins with nonclassic active center motifs pdf

Tài liệu Báo cáo khoa học: Molecular cloning and characterization of soybean protein disulfide isomerase family proteins with nonclassic active center motifs pdf

... 1D). GmPDIL-3a and GmPDIL-3b have twopredicted thioredoxin domains between amino acids65–164 and 403–481, and 68–167 and 406–508,respectively, corresponding to the a-domain and a¢-domain of ... and density (gÆmL)1)is indicated on the top. (B) Microsomes were treated without (lanes1 and 2) or with (lanes 3 and 4) proteinase K, in the absence (lanes1 and 3) or presence (lanes 2 and ... contribute to ER function and protein folding are beginning to emerge, and, importantly, knowledge concerning GmPDIL-3a and GmPDIL-3b can now be applied to the understandingof how divergent PDI...
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Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt

Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt

... cholesterol levels strictly and partially determine SREBP-2 and SREBP-1 cleav-age in mammalian cells for sterol regulation and synthesis of other lipids, respectively. Intriguingly,cleavage of ... elevated, and consequently,the levels of nuclear SREBP-1c protein and lipogenesisare enhanced in the liver and adipose tissues. Intake ofenergy molecules such as sugars, carbohydrates and saturated ... SREBP-1c by saturated fatty acids and PU-FAs. Saturated fatty acids activate, and PUFAs suppress, SREBP-1c, leading to and protecting from hepatic insulin resistance and pancreatic b-cell insulin...
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