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Báo cáo y học: "HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat" pps

Báo cáo Y học: Conformational analysis by CD and NMR spectroscopy of a peptide encompassing the amphipathic domain of YopD from Yersinia potx

Báo cáo Y học: Conformational analysis by CD and NMR spectroscopy of a peptide encompassing the amphipathic domain of YopD from Yersinia potx

... onlytransitory, because a portion of YopD is also localized to the host cell cytosol [10]. In addition, we and others observedthat a yopD null mutant is constitutively induced forsynthesis of ... component of the Yop effectortranslocon of Yersinia. Mol. Microbiol. 39, 620–632.10. Francis, M.S. & Wolf-Watz, H. (1998) YopD of Yersinia pseud-otuberculosis is translocated into the cytosol of ... constructed with the VMDsoftware [36].Fig. 6. NMR structure of the amphipathic domain of YopD illustrating the hydrophobic and hydrophilic sidedness of the peptide. Thesidechainsare displayed for residues...
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Báo cáo y học: "A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting" pptx

... subjects; of these, 9 were judged as being unlikely to be related to study drug, 14 as being unrelated to study drug, 11 a sbeing possibly related to study drug, and 9 as being prob-ably related to ... weeks of long-term treatment. Importantly, improvements in symptoms of schizophrenia were not limited to clinician assessment of symptoms; improvement in quality of life measuredusing the WHOQOL-BREF ... study to evalua te the long-termefficacy and safety of aripiprazole for the treatment of schizophrenia. The study took place between August2006 and December 2008 at nine centers under the latest...
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Báo cáo y học: "Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases" ppt

... induction of these proinflammatorycytokines may be one of the important mechanisms of IL-32leading towards inflammation. Although the previous reportdid not demonstrate the synergizing effect of ... macrophages are known to be important sources of the inflammatory cytokines in the joints of arthritis patients. hIL-Figure 2IL-32 was abundantly expressed in the synovial tissues of rheumatoid arthritis ... presence of IL-32β. Therefore IL-32β had effects onmacrophages rather on than T cells in vivo, and the in vivoroles of IL-32β were mainly to induce other inflammatorycytokines rather than to activate...
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Báo cáo y học: "Does left atrial volume affect exercise capacity of heart transplant recipients" docx

... for attainment of a physiologically valid mea-sure of ventilatory efficiency. The retrospective nature of this study and relativelysmall sample size are the primary limitations of the pre-sent ... function and therefore, the left atrium may subsequently dilate to increase the reservoir capacity as a compe nsatory mechanism, whichin turn theoretically would maintain left atrial output in the presence ... quiterevealing. The dilatation of LAV might be also in part related to the surgical scar of the left atrial anastomosis. The sur-gical scar between the native and the donor atrium mayimpede correct...
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Báo cáo y học: " Psychiatric disorder in early adulthood and risk of premature mortality in the 1946 British Birth Cohort" pdf

... ID of 3 or more(22.0%) who typically have at least 5 psychiatric symptomsand were likely to have a psychiatric disorder; those withan ID of 2 (30.7%), who were mildly symptomatic with 1-4symptoms; ... mediators only led to a modest reduction in the effect. Sensitivity analyses which excluded the missingcategory from each of the confounders had little effecteither on the hazard ratios for psychi ... up to 36 years (n = 251) and physical health status at 36 years (n-61).** Index of definition: 1 = no symptoms; 2 = 1-4 symptoms; 3-7 = 5 or more symptoms.Henderson et al. BMC Psychiatry 2011,...
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Báo cáo y học: "A novel nucleotide insertion in S gene of hepatitis B virus in a chronic carrier" pps

... alter HBsAg antigenicityand affect the binding capacity of anti-HBsAg [25,26].Due to overlapping of S gene with P gene, variation in Sgene may affect catalytic activity of reverse tran-scriptase(rt) ... 3-nt(TCA) deletion from nt491 to nt493(fig-ure 1). Phylogenetic analysis by Mega3.1 software indi-cated they belonged to genotype B.Amino acid sequence analysis of HBsAgaa sequences were deduced ... sequences of 20 clones. Lys122, Lys160 and Pro127 indicated theybelonged to subtype adw2.Compared with consensus sequence of Chinese isolatesretrieved from GenBank with same genotype/subtype,clone1-clone11...
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Báo cáo y học: " Decorin and TGF-β1 polymorphisms and development of COPD in a general population" ppt

... matrix metalloproteases and tis-sue inhibitors of metalloproteases.[27,28] Furthermore,decorin is the natural inhibitor of TGF-β1 and may there-fore influence the repair process in the lung ... variables. The results of these analyses showed no change in estimates of the variables in the model or a better fit of the model,which indicates that there was no bias due to regression- to -the- mean. ... datasets to generate adistribution of the beta estimates for additional FEV1decline of the homozygous minor allele genotype com-pared to FEV1 decline of the homozygous wild type allelegenotype...
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Báo cáo khoa học: "Indications and recommended approach for surgical intervention of metastatic disease to the gallbladder" ppt

... lymphadenectomy of the hepatoduodenal ligament[18]. In their review, the authors divided the manage-ment of melanoma of t he gallbladder to pr imary andmetastatic lesions. Their review of the ... surgery isan option. Because of the two cases of port-metastasesand the small sample size of their study, the authorswere unable to advice whether a cholecystectomy via alaparoscopy was a ... purposes [16]. The role of laparoscopic cholecystectomy in the management of MMGBLaparoscopic cholecystectomy (LC) has been describedfor the management of these lesions. The first report of LC for...
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Tài liệu Báo cáo Y học: BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro Implications in the BIGH3-linked corneal dystrophies pptx

Tài liệu Báo cáo Y học: BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro Implications in the BIGH3-linked corneal dystrophies pptx

... decades of life and severely impair visualacuity in adulthood. Their therapy is restricted to keratopl-asty and phototherapeutic keratectomy by Excimer laser.Unfortunately, the benefits of these therapies ... peptides to adopt ab-pleated sheet configuration and to form amyloid. The CONH2-terminus of the peptides analyzed has an inhibitoryFig. 6. Secondary structure determination of the peptides by FT-IRspectroscopy ... it was the fastest to precipitate into amyloid fibrils. On the contrary, the mutated S110)131 and the native R110)131 proved to have the least tendency to form amyloid fibrils as shown byThT fluorescence...
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Báo cáo Y học: Introducing Wilson disease mutations into the zinc-transporting P-type ATPase ofEscherichia coli The mutation P634L in theÔhingeÕ motif (GDGXNDXP) perturbs the formation of the E2P state pdf

Báo cáo Y học: Introducing Wilson disease mutations into the zinc-transporting P-type ATPase ofEscherichia coli The mutation P634L in theÔhingeÕ motif (GDGXNDXP) perturbs the formation of the E2P state pdf

... ATPase activity of the wild-type andmutated enzymes. TheATPaseactivity(percentageoftheactivityofthewild-type) present in membranes shown. The ATPase activity presentin the a bsence of zinc has ... with the recent determination of the crystal structure of the sarco-plasmic Ca-ATPase [4], analysis of these and other WDmutant homologues may help in further d elineating the keyfeatures of these ... translocatedthrough the membrane simultaneously with the conversion of the e nzyme from the E1P into t he E2P state. Finally, the aspartyl phosphate is hydrolyzed and t he enzyme returns to the initial...
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