Báo cáo y học: "CD4+ T cells spontaneously producing human immunodeficiency virus type I in breast milk from women with or without antiretroviral drugs" potx
Báo cáo y học: "CD4+ T cells spontaneously producing human immunodeficiency virus type I in breast milk from women with or without antiretroviral drugs" potx
... 53:135-148.doi:10.1186/1742-4690-8-34Cite this article as: Valea et al .: CD4+ T cells spontaneously producing human immunodeficiency virus type I in breast milk from women with or without antiretroviral drugs. Retrovirology 2011 ... cells indicated that the virus particles secreted into the cell culture supernatants from breast milk cells are infectious. Taking into account thelow bioavailability of ritonavir/lopinavir in breast ... physiologically activated in HIV-1 infectedindividuals, we hypothesized that some of the breast milk- derived T cells latently infected by HIV-1 revert toproductively infected cells upon activation in...
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Báo cáo y học: "Phenotypic and genotypic characterization of Human Immunodeficiency Virus type 1 CRF07_BC strains circulating in the Xinjiang Province of China" pot
... charges in theirV3 loop become more resistant to the anti-V3 neutralizingantibodies [21]. This selective force is continuouslyenriching the R5 viruses during long-lasting persistentinfection. The ... viruses. In conclusion, this study, for the first time, characterizesthe genotypic and phenotypic properties of HIV-1CRF07_BC strains circulating in Xinjiang province ofChina, in comparison with those ... successfully isolated 14 viruses with in vitro infectivity, but excluded two of them from this study because these two viruses were obtained from the patients who had used antiretroviral therapeutics(ART)...
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Báo cáo y học: "Microarray study reveals that HIV-1 induces rapid type-I interferon-dependent p53 mRNA up-regulation in human primary CD4+ T cells" doc
... viral proteins that can bind p53 might inhibit itspro-apoptotic activity, allowing more cells to becomeeither productively or latently infected with HIV-1 [52]. Itcan be postulated that the ... mRNA in response to virus infection. Thisprocess is aimed at preventing the spread of infection byallowing a more rapid induction of apoptosis. It is impor-tant to note that an increase in p53 ... JE, Tremblay MJ: Presence of host ICAM-1 in laboratory and clinical strains of human immunodeficiency virus type 1 increases virus infectivity and CD4(+) -T- celldepletion in human lymphoid tissue,...
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Báo cáo y học: "Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression" doc
... uniquetranscriptional milieu in this evolutionarily conserved target cell of all lentiviruses. Importantly, transient trans-complementation by ex vivo nucleofection with the Tat-interacting protein Cyclin ... importantly, while integrantswere readily amplified by the newly developed PCR strat-egy at this late time point in Rat2 cells infected with the IN wt vector, provirus formation could not be detected ... Parental Rat2 cells were infected with VSV-G pseudotyped HIV-1 GFP vectors carrying either a wildtype integrase (IN wt) or catalytically inactive integrase (IN( D64V)). Where indicated, efavirenz...
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Báo cáo y học: "egulatory T cells in rheumatoid arthritis" ppsx
... healthy individuals, where theyretain their capacity to initiate autoimmune inflammation [2],negative selection in the thymus is not sufficient to preventthe activation of self-reactive T cells ... ofCD4+CD25high T cells from patients with active RA with regard to their ability to suppress pro-inflammatory cytokineproduction that reverts after treatment with TNF-neutralizingagents. Additional ... assays in vitro. In thesynovium, Tregs might be inhibited by different mechanismssuch as inflammatory cytokines including TNF, or stimulationby antigen-presenting cells, which in concert might...
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Báo cáo y học: "Regulatory T cells in systemic lupus erythematosus: past, present and future" pot
... positively corre-lated with disease activity, and the suppressive function ofthese cells was intact in cultures without antigen-presenting cells. The functional activity of both patient and healthycontrol ... Foxp3+CD4+ cells and correlations with disease activity in SLE may be explained by a variability ofdisease activity in the patients studied. Investigators whoreported decreased percentages probably studied ... of T- cellproliferation in vitro. Tregs also inhibit T- cell migration,differentiation and apoptosis. Moreover, the principal target ofTreg activity is probably antigen-presenting DCs rather than...
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Báo cáo y học: "Mouse T-cells restrict replication of human immunodeficiency virus at the level of integration" potx
... characterized by dominant inhibitory activities,can interfere with lentiviral replication in a species-spe-cific manner. Of potential relevance in the rodent context,the incorporation of the cytidine ... NIH 3T3 fibroblasts infected with either the integration-competent (IN wt) HIV-CMV-GFP or an integration-defective iso-genic HIV-1 vector (IN( D64V)), the latter carrying a cata-lytic core mutation in integrase ... Leavitt AD, Robles G, Alesandro N, Varmus HE: Human immuno-deficiency virus type 1 integrase mutants retain in vitro inte-grase activity yet fail to integrate viral DNA efficientlyduring infection....
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Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain potx
... [38].Accordingly, it is possible that the mechanism of membraneinteraction and destabilization is different in the case of Ab,but it is fair to say that the similarity with the fusion domainof a virus ... data were multi-plied by shifted sine functions (COSY) or lorentz-to-gausswindows (NOESY, TOCSY) in the direct dimension, andby shifted sine or sine square functions in the indirectdimension. ... temperature can be changed within fairly largeranges without peptide precipitation. HFIP was chosen in view of its solvent power and also its ability to stabilizehelical structures. In fact,...
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Báo cáo y học: "A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting" pptx
... period.Results from this study suggest that patients requiringa switch in antipsychotic medication can benef it from switching to aripiprazole treatment in both the shortand long term. In this study, ... abnormalities while receiving treatment with other antipsychotic agents may benefit from switchingto aripiprazole.Hyperprolactinemia, which is associated with someantipsychotic treatments, ... reaction to any antipsy-chotic medication (including but not limited to haloperi-dol, chlorpromazine, thioridazine, pimozide, risperidone,quetiapine and ziprasidone) . Subjects with any clinicalcondition...
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Báo cáo y học: "Decreased levels of soluble amyloid β-protein precursor and β-amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus" ppsx
... Sahlgrenska UniversityHospital or at Karolinska University Hospital. The patientswere consecutively incorporated into the study. Thepatients underwent a thorough clinical examination by anexperienced ... showed that SLE patients with MRI findings compared with those without MRI findings had significantly higherCSF-tau levels. These increases reflect the neuronaldamage of the brain in SLE patients. ... brain pathology. Thisfinding, together with increased intrathecal levels ofTGF-β, indicates an ongoing destructive parenchymatousprocess in the SLE brain. In addition, the present study provides...
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