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Báo cáo y học: "The rise of Bioscience in the East" pptx

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Báo cáo y học: "Antiviral therapy of HCV in the cirrhotic and transplant candidate"

... against Cirrhosis), is a multicenter study of the potential benefit of prolonged peginterferon therapy in mitigating the progression of fibrotic liver disease. [8] In this study, 391 of the ... costly and has not been studied rigorously in a randomized controlled format to assess their value and impact on efficacy of therapy although they are now widely used in patients receiving interferon ... factors, specifically G-CSF and erythropoietin, has allowed more aggressive dosing of interferon and ribavirin. [13, 14] Finally, growing experience with antiviral therapy in this high-risk...
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Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx

Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx

... ligand binding domains.By modeling the human PXR ligand binding domain wehave identified and mutated two polar residues in the puta-tive ligand binding pocket which differ between the humanand the ... determinant for the transcrip-tional regulation of the drug metabolizing enzyme family of heme-containing monooxygenases P450 CYP3A [1–4].Consequently this nuclear receptor is likely to play a ... likely to be involved in ligand binding.Since the initiation of this study the crystal structure of the human receptor has been published [23]. This has allowed usto compare our model with the...
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Báo cáo y học: "A role of ygfZ in the Escherichia coli response to plumbagin challenge" pdf

... critical,single alanine-substitution mutants of YgfZ were created in the fingerprint region. These YgfZ variants were thenassessed for the ability to restore plumbagin resistance in the ΔygfZ strain. ... activities of different YgfZ constructs to support the growth of the ΔygfZ E. coli strain in the presence of plumbagin. Plasmids were separately transformed into the ΔygfZ strain and assayed for the diameters ... conceptionthat YgfZ behaves in a mechanism different from that of SodA as to resolving the threat of plumb agin. One of the likely roles of YgfZ involved is possibly to accelerate the breakdown of plumbagin.Determining...
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Báo cáo y học: " Oxidative modification of albumin in the parenchymal lung tissue of current smokers with chronic obstructive pulmonary disease" docx

... primarily from the lung or the s ys-temic circulation . Ultimately independent of the source of HSA, decreased levels of the protein, could contributeto the oxidative burden within the lungs of ... burden both directly as aresult of smoking and indirectly by the release of ROSwhich may not be adequately counterbalanced by the pulmonary antioxidant systems, resulting in net oxida-tive ... marker of oxidative stress in patients with chronic renal failureand individuals on hemodialysis therapy (12). In light of these findings the quantification of carbonyl residuesmay provide further...
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Báo cáo y học: "Contemporary epidemiology of gout in the UK general population" pot

... cyclosporine therapy. Use of gout-specific treatment has remained relatively constant in recent years except for an increase of colchicine.IntroductionGout is a common and excruciatingly painful inflamma-tory ... randomly selected 50,000 controls using densitysampling. This was done by generating at random adate encompassed within the study period for each of the members of the study population. If the ... person-years in women of 40 to 49 years, to 3.6 in women of 70 to 79 years. Our results are in line with aprior study [16] that reported an incidence rate of gout of 0.6 per 1,000 person-years in...
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Báo cáo y học: "Patients'''' recollections of experiences in the intensive care unit may affect their quality of life" doc

... of their condition until late in their ICU stay and some of them only after their discharge to the ward. However, during their ICU stay they continue to havean emotional life, in a mixture of ... procedures, maintenance of the day/night cycle, minimisa-tion of sensory stimuli and minimisation of noise and lights.Although for some patients the noise of alarms and seeingstaff around them may be ... family ties in the Portuguese culture. Pain came in fourth place in the ranking of stressors. This finding, togetherwith the need to preserve factual memories [2,18], shouldencourage revision of...
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Báo cáo y học: "Molecular evolution of neuropeptides in the genus Drosophila'''' potx

... profiling of the ring gland The ring gland contained the adipokinetic hormone (AKH;pQLTFSPDWa), the AKH processing intermediate pQLTFSP-DWGK, myosuppressin (MS), corazonin, corazonin3-11, the pyrokinins ... (m/z)% intensity% intensity% intensity% intensity% intensity% intensity% intensity% intensityD. virilisD. mojavensisD. pseudoobscuraD. sechellia(dii)(cii)(bii)(aii)Genome Biology 2008, ... (m/z)% intensity% intensity% intensity% intensity% intensity% intensity% intensity% intensity(cii)(dii)D. virilisD. mojavensisD. pseudoobscuraD. sechellia(bii)Genome Biology 2008,...
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Báo cáo y học: "New levels of sophistication in the transcriptional landscape of bacteria" pot

... known to be involved in bacterial Type I toxin-antitoxin systems [13] and the control of incompatibility of some plasmids [14], but has not been implicated in controlling the expression of virulence ... many other noncoding RNAs (Figure 1). Some of these are catalytic, such as RNase P, or interact directly with proteins, like the 6S RNA that interacts directly with σ70-containing RNA polymerase ... regulatory systems [2]. In the past decade it has become apparent that the various forms of noncoding regulatory RNA (previously considered as intergenic junk) play important roles in the global...
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Báo cáo y học: "Frequent activation of EGFR in advanced chordomas" pptx

... along the mid line, andmost often in the caudal spine or the base of the skull.They are slowly growing masses with the tendency todestroy t he surrounding bone and to infiltrate adjacentsoft ... USA).Receptor tyrosine kinases (RTK) activation profiling usingantibody arrays The activation of RTK and their downstream signalingpathways were analyzed using the Proteome Profiler™Array kits (ARY001 ... of PDGFRB only in five out of 12 (42%) chord omas, usingthesameantibodyRTKarraysandusingthevalueof the mean plus the standard deviation with in an array as the c ut-off. However as indicated by statistical...
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Báo cáo y học:

Báo cáo y học: "The rise of Bioscience in the East" pptx

... notnecessarily reflect those of his employer, the National Institutes of Health(NIH). Work in KTJ’s laboratory is supported in part by intramural fundingfrom the National Institute of Allergy and Infectious ... J, Qu S, Yu X, Meng Z, He X, Jiang S,Shao Y: Phenotypic and genotypic characterization of humanimmunodeficiency virus type 1 CRF07_BC strains circulating in the Xinjiang Province of China. Retrovirology ... importantroles to play in fostering the quantity and qual ity of scientific excellence in the up-and-coming fledglingnations.Acknowledgements The opinions expressed are the author’s personal...
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