Báo cáo y học: "Recently published papers: Sugar, soap and statins – an unlikely recipe for the critically ill" pdf

... than the first few days of the illness,although they proposed no reason for the observed increasein mortality in the group treated for fewer than 3 days [5].What is clear is that hypoglycaemia ... investigators have noticed an increase inhypoglycaemic events, similar to those reported by van denBerghe and colleagues. They therefore set out to identify the factors that may make this such a common ... ofdialysis) and incidence of hyperbilirubinaemia. The investigators suggested that, for the protective effect ofstrict normoglycaemia to be realized, the therapy must beestablished for longer than...

Báo cáo y học: " Recently published papers: Delivery, volume and outcome – what is best for our patient" pps

... delay. There is a lack ofinstitutional data and, as such, a few underperforming centresmay therefore have contributed to the majority of delayedtransfers, which may be explained by other factorsindependent ... availability of an intensivist outside workinghours and mortality was observed. This may in part beexplained by the excellent provision of ICU-trained doctors in The Netherlands. The authors do call for ... policy-makers go from here? Clearly there is a need for further prospective studies, and if these help elucidatesome of the critical factors then these factors may beaddressed. The problem may...

Báo cáo y học: "Recently published papers: dying Swans and other stories" pot

... three year period wasanalysed and corrected for age, gender and illness severity. The odds of death increased 7.4 times in morbidly obesepatients requiring intensive care for 4 days or more.Physiological ... those in the French study.Oropharyngeal decontamination with either CHX or CHX/COL reduced and delayed the development of VAP. Daily riskof acquiring VAP decreased: 65% and 55% for CHX and CHX/COL, ... be blinded and powered for mortality and length of stay.AminophyllineAnother attempt to improve outcome in out-of-hospitalcardiac arrest patients has, unfortunately, not returned anyimprovement...

Báo cáo y học: "Recently published papers: predictors, pressors and poietins" potx

... reactivity is attenuated by NADR but increased withAVP and to an even greater extent with F-180. The implication is that the desired pressor response may bespecifically V1 mediated and therefore ... treatment and so on.It remains important to pursue ways of minimising trans-fusions and the EPO agonists may indeed play a crucial part. The potential of other EPO agonists was recently highlightedin ... reduced by 50% in the AVP group and completelyprevented by the selective V1 agonist, FE 202158. Howeverin the latter group, the full prevention of this fluid and proteinleakage was reduced by 50%,...

Báo cáo y học: "Recently published papers: Pseudomonas, brain and bowel injury and novel cardiac therapies" ppsx

... initiation of antibiotictherapy. Analysis for type III cytotoxins was undertaken and results indicated that about 50% of the patients hadpersistence of type III secretory system cytotoxins. The resthad ... although there was not much impactCommentaryRecently published papers: Pseudomonas, brain and bowelinjury and novel cardiac therapiesUma M Bandarupalli and Gareth WilliamsUniversity Hospitals ... of the cytotoxins. The persistence of the cytotoxins was attributed to the delayto eradication of the micro-organisms, and hence the recom-mendation is for longer courses of antimicrobial therapy.Kollef...

Báo cáo y học: " Recently published papers: Topical issues in pharmacology" pptx

... recent paper on the effects of methylprednisolone inunresolving acute respiratory distress syndrome [10], and may account for a therapeutic modality by which high-dosesteroid therapy works. It ... time to shock reversal and effect onserum cytokine concentration. By day 3 the SequentialOrgan Failure Assessment score was lower in the hydrocortisone group than in the placebo group (P < ... ofsignificance because this proinflammatory cytokine has beencorrelated with severity of septic shock, and this may explain the quicker resolution of organ-related morbidity in the treatment...

Báo cáo y học: " Recently published papers: We are what we eat" pot

... ofgastrointestinal motility may be effective salt and waterbalance. In a study by Lobo and colleagues [4], prompted byCommentaryRecently published papers: We are what we eat?LG ForniConsultant, Worthing ... ofmortality risk in the critically ill. This was no doubt triggeredby the Acute Physiology and Chronic Health Evaluation(APACHE) III as well as the study reported by McCluskey and colleagues ... recent study reported by Yap and coworkers [7]. They retrospectively studied more than1000 patients over an 18-month period, their hypothesisbeing that serum hypoalbuminaemia may be predictive...

Báo cáo y học: " Recently published papers: New evidence for old debates, new drugs and some timely reminders" pps

... safe and inexpensive, and that there is nowgood evidence to support its routine use in the severestcases, it only remains for the optimal dose and duration oftherapy to be established.Other ... reported by Weber and colleagues [22].Sadly, adoption of this technique, in the UK at least, awaits the deliberation of the government and judiciary.Finally, if you have been seduced by the attractive ... developed respiratorydistress within 48 hours of extubation to receive standardtherapy or standard therapy plus NIPPV. They found nobenefit from this intervention. To their credit, the authorsacknowledge...

Báo cáo y học: "Recently published papers: of head injuries, high frequencies and haemodynamic optimization" pps

... however, is the association between mortality and transfusion. Vincent and colleagues used a propensity scoring system to identify twodistinct groups and control for confounders, and found an odds ... surgery, trauma and sepsis patients. Their findings confirmed further thatwhen therapy is aimed at improving oxygen delivery(especially in the severely ill, in whom control group mortalitywas ... pressures.Kern and Shoemaker [11] recently looked back at the successes of haemodynamic goal-directed therapy in a meta-analysis of randomized controlled studies aiming for normalor supranormal values...

Báo cáo y học: "Recently published papers: A number of treatment controversies" pptx

... sedation,haemodynamic stability and time to extubation, among others.Unsurprisingly, the studies showed wide clinicalheterogeneity and this precluded formal statistical analysis.Although the authors ... and ICU days and consequently outcome, and that a sedation protocol including daily cessation ofsedative agents is of benefit. However, is any one agent orgroup of agents superior to the others? ... avoidunnecessary allogenic red blood cell (RBC) transfusion. The critically ill are at high risk for receiving RBC transfusion [11], and this is partly due to bone marrow impairment and inappropriately low...

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