Báo cáo y học: " Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody" ppsx
Báo cáo y học: " Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody" ppsx
... interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody Retrovirology 2010, 7:38Willett et al. Retrovirology 2010, 7:38http://www.retrovirology.com/content/7/1/38Page ... the virus- receptor interaction may not simply be a modulation of binding affinity, ratherit could represent a shift in the way the Env and receptorinteract. The two modes of interaction may ... mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibodyBrian J Willett*, Martin Kraase, Nicola Logan, Elizabeth L McMonagle, Ayman...
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Báo cáo Y học: Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules pptx
... mutation in the p51 subunit of HIV-1 RT [55]. The introduction of this mutation into RTsignificantly diminishes the ability of TSAO to bind to andinhibit the enzyme [55] and accordingly TSAO-e3T ... (discussedbelow).Peptide-based inhibitors of PR dimerizationShort synthetic peptides corresponding to the amino-acidsequences of the N- and C-termini of HIV-1 PR have beenshown to inhibit proteolytic activity by binding ... protein–protein interactions in such a way that the contacts between the two connection subdomains are alsointrinsically asymmetric. Thermodynamic evaluations of the association between the p66...
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Báo cáo y học: "Modulation of granulocyte-endothelium interactions by antileukoproteinase: inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium" ppt
... Berlin, Germany). The phase contain-Figure 1Inhibition of leukocyte interaction with the postcapillary endothelium by ALP in vivoInhibition of leukocyte interaction with the postcapillary endothelium ... by ALP in vivo. (a) Inhibition of leukocyte rolling along the postcapillary endothelium by antileukoproteinase in vivo. The results show the frac-tion of leukocytes rolling along the endothelium ... hours,inflammatory cell responses in the synovial tissue were clearlyprovoked. Activation by inflammatory stimuli after antibodytransfer to the mice was indicated by increases in leukocyterolling...
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Báo cáo y học: " Modulation of HIV-1-host interaction: role of the Vpu accessory protein" pps
... molecule is inserted into the virus while the other is anchored into the cellular membrane. (B) Tethering by incorporation of one of the molecule anchors in the virus and the other in the cellular ... resistance displayed by the chimpanzee Tetherinto the Vpu protein originating from the SIVgsn/mon/mus lineage results from the high sequence variability in the TM domain of Tetherin reported between ... domain of Tetherin to Vpu isrepresented by similar colour pairing. The deletion of the five aminoacids in human Tetherin cytoplamic tail is represented by the absence of the D/GDIWK sequence. The...
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Báo cáo y học: " Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat" pptx
... Since apoptosis mediated by Tat partlyrelies on the interaction of Tat with tubulin [14-17], wehypothesized that zinc binding might play a role in the modulation by Tat of the microtubule dynamics.Thus, ... reversibility of the majorpart of the holo-Tat-induced turbidity increase at 10°Cindicate that holo-Tat mainly induces the formation of microtubules. As a consequence, the increase of the tur-bidity ... remain monomeric in the presence of zinc[6,21,24]. Moreover, while the binding of zinc wasreported to be dispensable for the binding of Tat to the TAR sequence [19] and for the role of Tat in the...
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Báo cáo y học: "Modulation of the transcription regulatory program in yeast cells committed to sporulation" ppt
... (h)Time in YPD (min)Time in SPM (h)Time in YPD (min)Time in SPM (h)Time in YPD (min)Time in SPM (h)Time in YPD (min)Time in SPM (h)Time in YPD (min)Time in SPM (h)Time in YPD (min)http://genomebiology.com/2006/7/3/R20 ... genesTime in SPM (h)Time in YPD (min)Time in SPM (h)Time in YPD (min)Time in SPM (h)Time in YPD (min)Time in SPM (h)Time in YPD (min)Time in SPM (h)Time in YPD (min)Time in SPM (h)Time in YPD ... genes210846539020540704RepressedInsulatedInducedTime in SPM (h)Time in YPD (min)Time in SPM (h)Time in YPD (min)Time in SPM (h)Time in YPA (min)Time in SPM (h)Time in YPA (min)Time in SPM (h)Time in Glucose (min)Time...
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Báo cáo y học: "Does switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect health-related quality-of-life and medication satisfaction for children with attention-deficit/hyperactivity disorder&
... as measured by the AIM-C, was also generallyimproved over the course of the study. At baseline, mostcaregivers indicated inconsistency in their child's behavioracross the day in contrast ... socialinteractions since beginning the study medication, and91.9% were satisfied with the efficacy of the study medi-cation on their child's attention. The majority of caregiv-ers (93.1%) indicated ... recently published study evaluatingMTS wear times of 4 and 6 hours, instead of the 9-hourwear time used in this study, suggests that some late dayside effects may be attenuated by early removal of...
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Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"
... that bind to the SH2 domains. The tandem SH2 domains bind to Tyr-627 and Tyr-659 simultaneously in a specific orientation, in which Tyr-627 binds to the N-SH2 domain and Tyr-659 binds to the ... previously that G/G of the PTPN11 gene encoding SHP-2 increased the risk of gastric atrophy among the seropositive subjects [18]. The present study examined the association of a polymorphism of ... diagnosis of cancer. In summary, the Gab1 A/A was associated with the low risk of H. pylori infection while the G/A and A/A genotypes together may increase the risk for gastric atrophy. The biological...
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Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc
... increase from the apoenzyme to the Mn2þ-containing enzyme, loss of the metal cofactor could be the limiting step in BLXIinactivation. Higher Eavalues of inactivation for the Co2þ–enzyme and the ... on xylose, the apoenzyme activity was tested on both sugars in the presence of increasing concentrations of each cation (in the chloride form; Fig. 4). In the absence of metal, the apoenzyme ... & Ringe, D. (1994) Role of the divalent metal ion in sugar binding, ring opening, andisomerization by D-xylose isomerase: replacement of a catalyticmetal by an amino acid. Biochemistry 33,...
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Báo cáo Y học: Holliday junction binding and processing by the RuvA protein of Mycoplasma pneumoniae ppt
... highconservation of the sequences forming the pin in th emajority of bacteria with the exception of two Mycoplasmaspecies and one of Ureaplasma. In t he RuvA p roteins from these organisms the pin sequence ... Holliday junction and allow subsequentloading of RuvB and RuvC. A negatively charged pin pro-jecting from th e centre limits b inding of linear duplex DNA. The a mino-acid sequences forming the pin ... the loading of two RuvB ring helicases on opposing duplexesand of a dimer of RuvC endonuclease on the other face of the junction in the space between the RuvB rings [ 7,8]. Th eRuvAB proteins...
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