... assays, acquisition of data, statistical analysis, and drafting of the manuscript. DE measured levels of autoan-tibodies and assisted in apigenin therapy injections, cellularimmunologic assays, ... 2007,179:7121-7127.36. Liang YC, Huang YT, Tsai SH, Lin-Shiau SY, Chen CF, Lin JK:Suppression of inducible cyclooxygenase and inducible nitricoxide synthase by apigenin and related flavonoids ... required for inducing apoptosis.Conclusions Apigenin inhibits autoantigen-presenting and stimulatory functions of APCs necessary for the activation and expansion of autoreactive Th1 and Th17 cells and...