Báo cáo y học: " HIV vaccine: it may take two to tango, but no party time yet" doc

... hasthe greatest variety of HIV- 1 subtypes, but subtypes B andE are not common there. However, it seems relativelystraightforward to modify the RV144 components to match the subtypes that are more ... an individual vaccine, it will be difficult to dis-sect whether inclusion of AIDSVAX yielded any benefit.Possibly laboratory analysis can help to provide ananswer, but otherwise new human ... of only pieces of HIV- 1, not the whole virus, andtherefore cannot cause AIDS and both are intended forthose uninfected with HIV- 1, to educate their immunesystems to be able to fight off HIV- 1...

Báo cáo y học: "Glucose–insulin–potassium infusion in sepsis and septic shock: no hard evidence yet" docx

... of4.4–6.1 mmol/l) in patients admitted to surgical intensivecare units leads to marked reductions in morbidity andmortality [2]. However, in that study the investigators did notuse a GIK infusion; ... ofacute myocardial infarction is very promising, but that it will take a large randomized study to determine its effectivenessonce and for all [12].Recently, the Glucose–Insulin–Potassium Study (GIPS) ... [13]reached its conclusion. In that study 940 patients wererandomly assigned to primary coronary angioplasty with GIK(glucose 20% with 80 mmol potassium at a rate of 3 ml/kgbody weight/hour...

Báo cáo y học: "Applying the quality improvement collaborative method to process redesign: a multiple case study" doc

... trajec-tory into one; they did not redesign a diagnostic trajec-tory at the outpatients’ clinic; or the long throughputtimewasnotaresultofmanyvisitsbutofalongwait-ing list for one spec ific diagnostic ... contribute to this byassessing the applicability of this quality improvementmethod to process redesign. Process redesign aims to improve the organisation of care delivery in terms ofwaiting times ... ProstateHypertrophy100 E - + + Urology 1 (1)16. Colon cancer 100 E + + + Surgery; Gastroenterology;Radiology; Oncology4 (1)17. Varicose veins 150 E + + - Surgery; Dermatology 2 (2)+ Yes, - No; ...

Báo cáo y học: " Extracting key information from historical data to quantify the transmission dynamics of smallpox" doc

... we may not be able to find all theanswers to the following questions in a single historicaldata set, we may have to combine different data sets or to merge in information from laboratory experiments.(A) ... appropri-ately, it is critically important to clarify the heterogeneityof transmission. The above-mentioned critical coveragefor eradication assumes a randomly mixing population, but it has been ... majority of cases in the early 20th century in theUnited States, where it remained the only form of small-pox from the 1930s until its eradication [34]. The epide-miology of variola minor and its...

Báo cáo y học: " HIV transmission should be decriminalized: HIV prevention programs depend on it" docx

... transmission may bea significant deterrent to being tested for HIV infection inthe first place. After all, an individual who does not knowthat he is HIV positive cannot logically be accused of itstransmission. ... when it hasbeen possible to prove wilful transmission. In almost allsuch instances, defence lawyers have seized upon the dis-credited notion that HIV may not cause AIDS in the firstplace, to ... number not for citation purposes)RetrovirologyOpen AccessEditorial HIV transmission should be decriminalized: HIV prevention programs depend on it Mark A WainbergAddress: McGill University AIDS...

Báo cáo y học: "HIV DNA and Dementia in Treatment-Naïve HIV-1-Infected Individuals in Bangkok, Thailand"

... cells may be particularly suited as sanctuaries for virus because HIV- 1 DNA (HIV DNA), compared to HIV RNA, is less affected by cur-rent treatment regimens [6-9]. Additionally, these nondividing ... <0.001 HAD: HIV- 1-associated dementia; ND: no dementia Table 2. HIV DNA Copy and Total Burden in PBMC and Subsets HIV DNA Copy per Total HIV DNA Copy Calculated From Diagnosis PBMC CD14/CD16 ... CD14/CD16 phenotype, the current study attempts to address the question whether a spe-cific PBMC subset (M/MФ or CD4 lymphocytes) har-bors HIV DNA. We undertook the current study to test the hy-pothesis...

Báo cáo Y học: What does it mean to be natively unfolded? pptx

... alpha-lactalbumin, lysozyme, and alpha-lactal-bumin/lysozyme chimeras allows the elucidation of critical factorsthat contribute to the ability to form stable partially folded states.Biochemistry 40, 2138±2147.26. ... atively unfo lded proteins is i ndirectly con-®rmed by their extremely h igh s ensitivity to proteasedegradation in vit ro [4,5,54±59].Table 1. Hydrodynamic characteristics of the natively unfolded ... 415±422.16. Wakabayashi, K., Yo shimoto, M., Tsuji, S. & Takahashi. H.(1998) Alpha-synuclein immunoreactivity in glial cytoplasmic in-clusions in multiple system atrophy. Neurosci. Lett....

Báo cáo y học: "HIV-1 Capsid Assembly Inhibitor (CAI) Peptide: Structural Preferences and Delivery into Human Embryonic Lung Cells and Lymphocyte" pptx

... peripheral lymphocytes (PTL) from Institute of Pathology, University of Hei-delberg. PTL were isolated from 10 ml native venous blood from a healthy donor by a lymphocyte prepara-tion with Lymphoprep™ ... Introduction of 9-fluorenylmethoxycarbonyl, tri-chloroethoxycarbonyl, and benzyloxycarbonyl amine protecting groups into O-unprotected hydroxyamino acids using suc-cinimidyl carbonates. Can J ... to a BioShuttle-molecule additionally improved its solubility. Under the conditions described, the HIV- 1 CAI peptide was transported into living cells and could be localized in the vicinity...

Báo cáo y học: "Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valproate" pps

... choline concentrations oractivity. An in-vitro study suggested that valproate may inhibit choline acetyltransferase activity [34]. In one study9 patients taking either lithium or valproate were exam-ined ... adetailed, but non-standardized, psychiatric interview.They were excluded if there was any personal history, orimmediate family history, of psychiatric disorder. Forpatients, diagnoses were ... treated with valproate and an atypicalantipsychotic.Annals of General Hospital Psychiatry 2004, 3:13 http://www.general-hospital-psychiatry.com/content/3/1/13Page 2 of 7(page number not for citation...

Báo cáo y học: " HIV-1 resistance conferred by siRNA cosuppression of CXCR4 and CCR5 coreceptors by a bispecific lentiviral vector" ppt

... R,Thorstensson R, Fenyo EM, Bjorling E: Primary human immuno-deficiency virus type 2 (HIV- 2) isolates, like HIV- 1 isolates,frequently use CCR5 but show promiscuity in coreceptorusage. J Virol ... hematopoieticprogenitor cells and embryonic stem cells efficiently trns-duced by optimized retroviral hybrid vectors. Gene Therapy2002, 9:477-487.46. An DS, Koyanagi Y, Zhao J, Akkina R, Bristol G, Yamamoto ... possibil-ity exists that over expression of foreign siRNAs in a cell may have undesirable effects such as saturating the endog-enous RISC complex and consequent toxicity. Such a pos-sibility needs to...

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