... combination. The singleexception is the addition of weak base (e.g. tris-hydroxymethylaminomethane) [6], which is normally absent from body fluids.ReviewClinical review: The meaning of acid–base abnormalities ... determinant of pH, as well as of otherdependent variables such as [HCO3 – ]. All acid–base interventions, including fluid administration, act through SID,ATOTand PCO2, alone or in combination. ... abnormalities in the intensive care unit – effects of fluid administrationThomas J MorganSenior Specialist, Adult Intensive Care, Mater Misericordiae Hospitals, Brisbane, AustraliaCorresponding author:...