Báo cáo khoa học: "Procalcitonin testing has the potential to reduce unnecessary antibiotic use in patients with suspected lower respiratory tract infections" ppsx

Tài liệu Báo cáo khoa học: A role for the intersubunit disulﬁdes of seminal RNase in the mechanism of its antitumor action docx

... A role for the intersubunit disulﬁdes of seminal RNase in the mechanism of its antitumor action Aurora Bracale1,*, Francesco Castaldi1,*, Lucio Nitsch2and Giuseppe D’Alessio11Dipartimento ... proposed for the mechanism of antitumour action of BS -RNase is based on the ability of the proteinto resist the neutralizing action of the cytosolic RNase inhibitor, a resistance due to the dimeric ... sulfhydryls.These results indicate that the intersubunit disulﬁde bonds of BS -RNase have a key role in the mechanism of antitumour action of the enzyme.Materials and methodsMaterialsIodoacetic acid...

Tài liệu Báo cáo khoa học: Functional dissection of the Schizosaccharomyces pombe Holliday junction resolvase Ydc2: in vivo role in mitochondrial DNA maintenance pptx

... 2843 Functional dissection of the Schizosaccharomyces pombe Holliday junction resolvase Ydc2: in vivo role in mitochondrial DNA maintenance Barbara Sigala and Irina R. TsanevaDepartment of Biochemistry ... crossover intermediate is thereforecrucial for the integrity and maintenance of DNA in allorganisms including mitochondrial DNA (mtDNA). Mitochondrial DNA amounts to about 15% of the DNA content in ... base-pairs in the centre of the junctions [19]. Detailedunderstanding of the functional role of these interactionswould require the crystal structure of the Ydc2 junction complex. In this study the...

Báo cáo khoa học: Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3-phosphoglycerate kinase doc

... structures of the wild-type, single- and double-mutant EhPGKs in aclosed conformation will certainly help to clarify the molecular arrangement in the guanine ring binding siteduring the binding of ... kinase gene for the correspondingamino acid residues present in the adenine nucleotide-dependent phospho-glycerate kinases and the recombinant proteins were puriﬁed. Kinetic anal-ysis of the ... and Val341 (patch C). The corresponding reported amino acid residuesinvolved in adenine binding in the other crystallizedproteins, as well as in the EhPGK identiﬁed in the predicted model, were...

Báo cáo khoa học: "Semantic Retrieval for the Accurate Identiﬁcation of Relational Concepts in Massive Textbases" ppt

... development of efficient methods of access-ing information in huge texts. Furthermore, userdemand has shifted toward the retrieval of moreprecise and complex information, including re-lational concepts. ... Comparison of X-1 and X-2 clarifies the effect of using the term ontology. Comparison of X-2 and X-3 shows the effect of the event ex-pression ontology. The results for X-3 indicate the maximum performance ... acceptable for real-timetext retrieval. The numbers of answers increasedwhen we used the ontologies, and this result indi-cates the efficacy of both ontologies for obtaining relational concepts...

Báo cáo khoa học: Crystal structure of the halotolerant c-glutamyltranspeptidase from Bacillus subtilis in complex with glutamate reveals a unique architecture of the solvent-exposed catalytic pocket docx

... unit, and the glutamate- binding modes are identical to eachother (Fig. 2A) . The a- carboxyl and a- amino groups of the bound glutamate are at the bottom of the pocket, and are held in this position ... questionsabout the role and signiﬁcance of the lid-loop in GGTcatalysis.During the preparation of this article, the crystal structures of Bacillus anthracis CapD, a GGT-relatedenzyme, in the absence ... crystallographic analysis of B. subtilis GGT in complex with glutamate. Another goal of this analysis was to determine the structural factors underlying the salt tolerance of B. subtilis GGT [15,16]. In...

Báo cáo khoa học: X-ray structure of glucose/galactose receptor from Salmonella typhimurium in complex with the physiological ligand, (2R)-glyceryl-b-D-galactopyranoside pdf

... protein. This kind of protein is exempliﬁed by the Thermus thermophilus protein, PDB entry 2B3B [28]. The mode of binding the monosaccharide is completelydifferent in terms of orientation of the ... calcium site of domain 2 was describedearlier, and tight binding of the ion was shown to con-tribute to the integrity of the protein structure [17,22]. The sodium site involves close interactions ... so-calledglucose ⁄ galactose-binding protein. Here, we report the X-ray structure of the Salmonella typhimurium protein bound to the physiologically relevant ligand, (2R)-glyceryl-b-d-galactopyranoside, ...

Báo cáo khoa học: N-Glycans of the porcine nematode parasite Ascaris suum are modiﬁed with phosphorylcholine and core fucose residues pot

... PC -modiﬁed glycans, the core fucose is a1,6-linked as in mammals. Other N-glycans fromnematodes also carry a1,3 -fucose on the proximal[21,26] and, uniquely, distal GlcNAc residues of the core ... residue. N-Glycans of Ascaris G. Poăltl et al.720 FEBS Journal 274 (2007) 714726 ê 2006 The Authors Journal compilation ª 2006 FEBS N-Glycans of the porcine nematode parasite Ascaris suum are modiﬁed ... [24] and O. volvulus[25]. These N-glycans contain the typical trimannosyl core, with and without core fucosylation, and carrybetween one and four additional N-acetylglucosamine residues. In these...

Báo cáo khoa học: Dynamic reorganization of the motor domain of myosin subfragment 1 in different nucleotide states docx

... kDa domain may become important in the actin myosin complex for the dissociation of the phosphateproduct. The effect of nucleotides on the flexibility of the motor domain The binding of ADP to the ... on the overall flexibility of the motor domain. The flexibility of the motor domain was different in the S1.ADP.AlF–4state from either apo-S1 or S1.ADP.Vi states. The largest reorganization of ... hydrolysis of ATP by the myosin induces aseries of conformational changes within the motor domain of myosin, which lead to the sliding of the thick and thinfilaments relative to each other. Some of the...

Báo cáo khoa học: "A step towards the detection of semantic variants of terms in technical documents Thierry Hamon and Adeline " potx

... reports the results of a preliminary experiment on the detection of semantic variants of terms in a French technical document. The general goal of our work is to help the struc- turation of ... synonym link between polaire and insensible. Moreover, tests carried out on dictionary samples show that the relevant links which 499 A step towards the detection of semantic variants of terms ... synonymy links between 1 542 simple terms are preserved. Table 1 shows the results of the filtering step in regard to the coverage of our corpus by the dictionary. 2.3 Second step: Detection of...

Báo cáo khoa học: "Molecular dissection of the quantitative inheritance of wood property traits in loblolly pine" pps

... been made toward the molecular dissection of the quantitative inheritance of wood property traits in loblolly pine (Pinus taeda L.) and several other forest tree species. QTL mapping experiments ... Diagram of the three-generation P. taeda pedigrees used in QTL mapping experiments. D.B. Neale et al .Wood property QTLsOriginal articleMolecular dissection of the quantitative inheritance of wood ... completely unknown. The focus of our research is to identify the genes control-ling wood property traits in loblolly pine (Pinus taeda L.), the most important timber species in the US. Our initial approachtoward...

báo cáo khoa học: "Primary sarcoma of the pancreas, a rare histopathological entity. A case report with review of literature" pps

... article as: Ambe et al.: Primary sarcoma of the pancreas, a rare histopathological entity. A case report with review of literature. WorldJournal of Surgical Oncology 2011 9:85.Submit your next manuscript ... incidence of pancreati c sarcoma after review 5000 cases of pancreatic cancer [1]. Amongstpancreatic sarcomas leiomyosarcomas tend to occurrelatively frequent [2]. Epitheloid sarcomas also knownas ... Basham : Carcinosarcoma of the pancreas. Arch Pathol Lab Med 2002, 126:1114-17.4. Feather HE, Kuhn CL: Total pancreatectomy for sarcoma of the pancreas.Ann Surg 1951, 134(5):904-912.5. Howard...

báo cáo khoa học: "Subcuticular microstructure of the hornet''''s gaster: Its possible function in thermoregulation" pptx

... point out that in hornets the abdomen is called agaster, because the first segment of the abdomen conjoinsduring the pupal stage with the three segments of the tho-rax and it is the remaining ... image of the tissue. The magnetic spins areexcited in slices of finite width, and for each slice, a singleimage is obtained. The relative intensity of each element of the imagedepends on the ... isonly the terminal part of the gaster, comprising 1/4-1/3 of the total gastral length and less so of the total volume,which contains most of the small and large intestine, the genitalia (degenerated...

Báo cáo khoa hoc:" Aortic distensibility measured by pulse-wave velocity is not modified in patients with Chagas'''' disease" pot

... properties are not modified in patients with Chagas' disease. So, our datasupport the conclusion that aortic distensibility is not impaired in patients with different forms of Chagas' dis-ease, ... 0.043).Conclusion: Carotid femoral pulse-wave velocity is not modified in patients with Chagas' disease,suggesting that elastic properties of large arteries are not affected in this disorder.The elastic ... at least in part, for this abnormalitycould be an impairment in arterial distensibility. Dataobtained in experimental studies support this issue by demonstrating that acute infection by trypanosoma...

báo cáo khoa học: " Multiple evidence for the role of an Ovate-like gene in determining fruit shape in pepper" pptx

... as of other genes like Sun also involved in controlling fruit shape in Solanaceae plants like tomato, pave the way to better understand the molecular mechanisms involved in controlling fruit shape ... al.: Multiple evidence for the role of an Ovate-like gene in determining fruit shape in pepper. BMC Plant Biology2011 11:46.Submit your next manuscript to BioMed Centraland take full advantage ... (WT) and of the VIGS infiltrated - with the antisense construct- plant (infiltratedplant 2) that was infiltrated in the stage of the cotyledons. The fruits of the infiltrated plant exhibit an average...

Báo cáo khoa học: "Procalcitonin testing has the potential to reduce unnecessary antibiotic use in patients with suspected lower respiratory tract infections" ppsx

... Procalcitonin testing has the potential to reduce unnecessary antibiotic use in patients with suspected lower respiratory tract infections Sadiq Al-Nakeeb1 and Gilles Clermont2 1 Clinical Fellow, ... calcitonin precursor concentrations, including procalcitonin, are raised in bacterial infections, but not in viral infections. Hypothesis Procalcitonin (PCT)-guided treatment of suspected lower ... with suspected lower respiratory tract infection as the main diagnosis. Intervention: Patients were randomly assigned to either standard care (n=199) or PCT-guided treatment (n=124). In the...

Xem thêm