... limb, predominantly in the feet and legs, foot drop, and hammer toes. The most frequent initial symptoms include foot drop, claw toe, and muscle wasting in the hands. Symptoms in the advanced ... advanced cases may include muscle waste in the hands and fore arms, neck and shoulder, vocal cords, which leads to scoliosis and malfunction in chewing, swallowing, or speaking. The defective ... characterized by NCVs overlapping both demyelinating and axonal range (25 - 45 m/s). Number of genes and gene loci has been involved in the pathogenesis of CMT, and despite of diversity of...