... family history, ethnicity, increasing age, centralobesity, physical inactivity, low HDL/high triglycerides,fasting glucose of 110 mg/dL or greater, gestational diabe-tes, hypertension, and polycystic ... Angiotensin Converting Enzyme CYP = Cytochrome P450 + Not all agents are appropriate for monotherapy. Inclusion in this table does not necessarily imply efficacy. * Currently FDA approved for use in ... portacaval shunting, thereby decreasing first passmetabolism; decrease in quantities and affinity of plasmaproteins, thereby increasing free-drug levels; increase in volume of distribution in patients...