... responding to conventional therapy [15].
Therefore, institution of AVP infusion in advanced septic
shock should not be guided by endocrinologic, but by
hemodynamic indications!
Whether the promising ... only in one-third of late septic shock
patients [12]. Additionally, the increase in arterial pressure
during AVP infusion occurs independently of plasma AVP
concentrations [9,13]. AV...
... multiple
organ dysfunction in early septic shock.
Introduction
Arginine vasopressin (AVP) is recommend ed by the Sur-
viving Sepsis Campaign to ‘be subsequently added to nore-
pinephrine’ in volume- ... supplementary infusion
of 0.067 U/minute AVP was more effective in restoring
MAP and reducing norepinephrine requirements than
the recommended low dose of 0.033 U/minute.
Interesting...
... emergency medical assistance was uncertain, and this
practice lead to a reduced number of unnecessary car ambulance missions. No accidents involving
the MEM were registered in the study period. ... Central
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Submit your manuscript here:
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Scandinavian Journal of Trauma, Resuscitation and Emergen...
... olfactory input pathways and a
hypothetical central neuron (grey circle) receiving those inputs. Information is transmitted as spiking activity. Typically, in the absence of any olfactory
stimulus, ... redundant inputs begins at a very early stage in olfactory
processing. Whether this unique wiring scheme enhances
the spatial comparison of simultaneous bilateral inputs [7]
or only incre...
... phosphorylation events in vivo, neither of
them is able to identify the exact kinase responsible for each
phosphorylation event. This problem is being addressed by
Mike Snyder (Yale University, New ... biology may be to
allow molecular biologists to move beyond the constraints of
studying only a few rather arbitrarily chosen model organ-
isms and out into the diversity of pathologically...
... strategy for RA, involving early
Commentary
The value of sensitive imaging modalities in rheumatoid arthritis
Peter C Taylor
The Kennedy Institute of Rheumatology Division, Faculty of Medicine, ... ability to distinguish between RA
joint effusion and synovial proliferation by MRI has been
greatly improved by the introduction of paramagnetic con-
trast agents. The early post-gadolinium synov...
... by cytokines,
particularly tumor necrosis factor α (TNF-α) [2].
Synovial tissue consists primarily of two distinct cell types: the
macrophage-like synoviocytes and synovial fibroblasts. The
synovial ... in all aspects of the patho-
genesis of arthritis. Hyperplasia of the synovial lining in RA is
due primarily to increases in the number of synovial fibroblasts.
Although the reason for...
... involved in the regulation of the cell cycle and apop-
tosis, including c-Myc, the tumor suppressor p53, and cyc-
lins [28]. Progression through G1 depends initially on
cyclin D-CDK4/6 protein ... later on cyclin
E-CDK2. Cyclin D1 is a key cell cycle regulatory protein,
known to be up-regulated by estrogen, an established
breast cancer mitogen [34]. The down-regulation of cyclin
D1 plays...
... and 0% eosinophils. His
ascites analysis revealed 3060 leukocytes/mm
3
with 64%
neutrophils, 18% lymphocytes, 15% plasmocytes, and 3%
macrophages. His Gram, acridine and auramine stains
were ... particular interest in this case is the rec-
ognition of potentially misleading features, such as the
presentation of symptoms with a quickly evolving septic
shock, and the presence of polymorp...
... Corwin HL, Gettinger A, Rodriguez RM, Pearl RG, Gubler D, Enny
C, Colton T, Corwin MJ: Efficacy of recombinant human ery-
thropoietin in the critically ill patient: a randomized, double-
blind, placebo-controlled ... function. Physiol Rev 1992, 72:449-489.
9. Jelkmann WE, Fandrey J, Frede S, Pagel H: Inhibition of erythro-
poietin production by cytokines. Implications for the anaemia
involv...