... rheumatologist answered a questionnaireinquiring about the initial symptoms as reported by the patient(type of initial joint symptoms, localization and distribution of initial joint symptoms, ... articleAntibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritisAnnette HM van der Helm-van Mil, Kirsten N Verpoort, Ferdinand C Breedveld, René EM Toes and Tom ... expression of citrullinated proteins, but mightbe the result of an abnormal humoral response. Intriguingly,this antibody response may occur years before any clinical symptoms, as shown by the presence...