... stimulates
Commentary
Role of iron in anaemic critically ill patients: it’s time to
investigate!
Michael Piagnerelli
1
and Jean-Louis Vincent
2
1
Resident, Department of Intensive Care, Erasme ... common problem in critically ill patients admitted to intensive care units. Many factors
can be involved in its development, including rapid alterations in iron...
... INTERPRETATION: posted earnings;
7. ANECDOTES;
8. OTHER: poems.
The goal of our research is to identify the
role of verbs, keeping in mind that event profile
is but one of many factors in ... still convinced that
our initial hypothesis on the role of verbs in
determining event profile was worth pursuing.
We believe that these results are a by-product
of lexical am...
... both
SH2 domains of SHP-2 in mitogen-activated protein
(MAP) kinase activation by the ErbB family of recep-
tors. A specific role for SHP-2 in MAP, but not c-Jun
amino-terminal kinase activation. ... previous
studies showing that EGFR is initially concentrated in
caveolae within lipid rafts, but rapidly moves out of
this membrane domain in response to EGF [7]. The
inefficient...
... School of Chemistry, University of Edinburgh, Edinburgh, UK
2 Delta Biotechnology Ltd, Nottingham, UK
Human albumin (66.5 kDa), a single-chain of 585
amino acids, is the most abundant protein in
blood ... pairs. Interestingly however, the disulfide
bonding pattern for the first 50 residues in domain I
differs from that of the other two domains. The first
two helices in the albumin...
... PAb240 from hybridoma cell lines detected the
presence of the epitope comprising amino acids 212–217 of
the p53 protein and represents the amount of p53 protein
loaded in each lane [30]. Phosphorylation ... proteins mutated at specific phos-
phorylation targets. Recombinant murine p53 proteins were expressed in
insect cells (using the baculoviral expression vector system) and in a...
... [35]. In addition the MYB
factor binding to these MYB binding sites are in the
same clade in the phylogenetic tree as GL1 [36]. We
therefore focused on these two putative binding sites. To
determine ... and MYC binding sites
Our finding that the activators can activate the TRY pro-
moter in transient expression assays together with the
finding that GL3 and GL1 bind to the TRY pr...
... problems of glucose
measurements arising from matrix effects, interferences and the
use of different assays.
Intensive insulin therapy in critically ill
patients
In the preceding issue of Critical ... measurement of
blood glucose values with immediate feedback of results. In
general, therefore, this is achieved by point -of- care testing, raising
the question of the best...
... analysis of the ability
of cystatin C and β
2
microglobulin to reflect creatinine clearance in
pediatric patients with AKI. The aim of this commentary is to review
the current state of AKI clinical ... and
β
2
microglobulin (β
2
M), to detect decreases in renal function
accurately in 25 critically ill children [1].
The authors conducted a careful study to obtain 24-h...
... shown that interactions between
KCs and endotoxin comprise the initiating event lead-
ing to hepatotoxicity in liver injury, including endotox-
emia and ischemia ⁄ reperfusion injury [14]. In our
studies, ... SJ
(2008) Regulation of hepatic drug-metabolizing enzyme
genes by Toll-like receptor 4 signaling is independent of
Toll-interleukin 1 receptor domain-containing adaptor
protein...
... involvement of ADAM17, a metalloprotease
involved in catalyzing ectodomain shedding of RTK
ligands. In nonstimulated cells, ADAM17 is normally
in complex with the integrin member a
5
b
1
and thus
inactive. ... also unclear why the effector protein
CagA itself can bind to the extracellular domain of inte-
grin b
1
because such high binding affinity would be
expected to inhibit t...