... theENTREZandBLASTsoftware (National Library of Medicine and National Institute of Health, Bethesda,MD, USA). ThePROSISpackage (Hitachi, San Bruno, CA,USA) was used for the analysis of multiple ... and sequence analysis of the endogenous ligands.Biochemistry 35, 1981–1987.29.Durairaj,M.,Leskiw,B.K.&Jensen,S.E.(1996)Geneticandbiochemical analysis of the cysteinyl residues of isopenicillin ... desaturation of aliphatic chains or theoxidative cyclization and the hydroxylation of substrates[18–22], and depend on the one-, two- or four-electronreduction of molecular oxygen. Most of these...