... creatinine at initiation of colistin; Cr2, highest value of creatinine during treatment with colistin; Cr3, serum creatinine 7 days after
completion of treatment with colistin; CVVHD, continuous ... for the severity of illness.
Because mortality rates in the region of 50–60% have been
reported in critically ill patients receiving inappropriate treat-
ment [1–7],...
... colistin as monotherapy; she had
received intravenous colistin therapy before aerosolized colis-
tin for 7 days and continued to receive the intravenous therapy
after the end of aerosolized therapy ... creatinine
value (mg/dl) on
the first day of
aerosolized
colistin
administration
1.1 5.2 1 0.4 2.4 0.6 0.8 0.8
Serum creatinine
value (mg/dl) at
the end of
aerosolized...
... abandonment of colistin in
clinical practice. As a consequence there is only a paucity of
physicians with clinical experience in the use of this class of
antimicrobials. The spectrum of activity of the ... describe the use of inhaled colistin in the treatment of multidrug-resistant Gram-negative
nosocomial pneumonia in a small group of patients. Alt...
... MDM2, thus mimicking the binding
of the helical portion of p53. However, one of the enanti-
omers of this racemic mixture of compounds was found
to possess higher affinity for the binding site as ... summarizes the growing body of knowledge regarding novel
therapeutic targets, enabling the concept of individualized targeted therapy for the treatment of FL.
Intr...
... adaptations in the eye in the human lineage.
In addition to the evolution of cN and cS crystal-
lins, even more specialization in the c-crystallins has
occurred with the loss of the N-terminal arm in the
ancestor ... lost the intron dividing the exons
encoding the first domain. The next step in the evolu-
tion of the c-crystallins was cS-crystallin,...
... activity of the re-grown clones was deter-
mined again by incubating the activated CPU at 37 °C and
using the same protocol as used in the primary screening
described above.
Determination of the half-life ... mutations in the
region following position 314 in CPU.
Fifty per cent of the residues mutated in the clones
selected from the first round of FIND
TM
ar...
... distribution of BsArb43B in the proximity
of the active site. Arabinotriose in the binding cleft is represented
using sticks. (B) Detailed view of the binding cleft with arabinotri-
ose. (C) Details of the ... with
arabinohexose [15], this loop makes the reducing end
of the carbohydrate chain bend towards the solvent,
probably optimizing binding of the carboh...
... frame encoded by the PR-1a gene, and differs
by only six amino acids from the PR-1a preprotein in the
N-terminal moiety of the protein. Most importantly, the
W38-1 pseudogene part of the W38-1::PR-1a ... a
distinct host response depending on the genetic constitution
of the plant and the pathogen. In an incompatible inter-
action, the pathogen remains localized...
... a certain level of TRa (Fig. 6A). As in the
HeLaTR cells, T3 treatment of the FRTL cells significantly
increased the level of the 4-1BB mRNA and decreased the
level of the BMP6 mRNA. Furthermore, ... modulated during both
early and late responses.
We also examined the expression of TRAF1 and TRAF2
because they interact and regulate the function of the 4-1BB
pr...
... ap-
plied to the links extracted from the dictionary.
Indeed, while the synonymy is sometimes very
contextual in the dictionary, the links appear in
the data without context information and ...
of wrong links is rather important in the list
presented to the expert: between 10 to 20 links
out of 396.
On the contrary, about ten wrong links are
due to the e...