... awaited [62].Marcos Intraglietta (La Jolla, CA, USA) presented anemerging alternative hypothesis to the dogma of maintainingoxygen delivery by maintaining oxygen carrying capacity (i.e.RBC transfusion). ... the wiser in clinically determining best PEEP, the evidence to datesuggests that the lung should be kept open to preventventilator-induced lung injury, although to achieve this wemay be simultaneously ... inspiratory and expiratory tidalvolumes early in acute respiratory failure, to identifyinsufficient ventilation as a consequence of leaks.Asynchrony as a result of leaks may be aided by the use...