Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 1 – receptor physiology" doc

... homologyexists between the V3R and the V 1 R [59]. The oxytocin receptor The OTR can be considered a ‘nonselective’ vasopressin receptor. The OTR has equal affinity for vasopressin and oxy-tocin, ... located on chromosome 12 and maps toregion 12 q14 -15 [44]. Functionally, the V 1 R activates G-proteins of the Gq /11 family. The α-subunits regulate the activ-ity of the β-isoforms of phospholipase ... Cell Endocrinol 19 94, 10 1:247-256. 71. Lee B, Yang C, Chen TH, al-Azawi N, Hsu WH: Effect of AVP and oxytocin on insulin release: involvement of V1b receptors.Am J Physiol 19 95, 269:E1095-E 110 0.72....

Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 2 – clinical physiology" pps

... Circulation 19 97,95 :11 22 -11 25.4. Landry DW, Levin HR, Gallant EM, Seo S, D’Alessandro D, OzMC, Oliver JA: Vasopressin pressor hypersensitivity invasodilatory septic shock. Crit Care Med 19 97, 25 :12 79 -12 82.5. ... peptide – Serotonin – Prostacyclin – Neuropeptide Y – Hypoxia CoronaryHypoxia PulmonaryBKCaAngiotensin II Coronary β-Adrenoreceptor Coronary, aortaThromboxane a2agonist Coronary Nitric ... http://ccforum.com/content/8 /1/ 152360. Boyle WA III, Segel LD: Attenuation of vasopressin- mediatedcoronary constriction and myocardial depression in the hypoxic heart. Circ Res 19 90, 66: 710 -7 21. 61. Wenzel V,...

Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf

... and of the cytokine-inducible neu-trophil chemoattractant. The presence of IL -11 did notaffect these chemokines. However, the BALF content of the complement C5a was reduced by IL -11 [24]. Thesedata ... radicals and hyperoxia The lung is particularly exposed to various inhaled toxic prod-ucts whose toxicity can be, at least partly, mediated by the generation of free radicals [1 4]. The oxidants ... associated with the development and progressionof many human disease states and inflammatory-relatedinjury, particularly of the lung [3]. Their ultimate regulationtherefore bears potential therapeutic...

Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx

... Cell Biol 20 01, 13 :16 7 -17 1.44. Semenza GL: HIF -1 and human disease: one highly involvedfactor. Genes Dev 2000, 14 :19 83 -19 91. 45. Semenza GL: Involvement of hypoxia-inducible factor 1 inhuman ... Normoxicinduction of the hypoxia-inducible factor 1 ααby insulin and interleukin -1 ββinvolves the phosphatidylinositol 3-kinasepathway. FEBS Lett 2002, 512 :15 7 -16 2.50. Haddad JJ, Land SC: A non-hypoxic, ... Physiol 20 01, 12 8 :17 -22. 17 . Fan J, Ye RD, Malik AB: Transcriptional mechanisms of acutelung injury. Am J Physiol Lung Cell Mol Physiol 20 01, 2 81: -L1037-L1050. 18 . Kupfner JG, Arcaroli JJ, Yum HK,...

Báo cáo y học: "Clinical review: Vasopressin and terlipressin in septic shock patient" pps

... of the pituitary body and certain other glandular organs. JPhysiol (Lond) 18 95, 18 :277-279. 31. Farini F: Diabetes insipidus and opotherapy [in Italian]. GazzOsped Clin 19 13, 34 :11 35 -11 39.32. von ... coronary artery. Am J Physiol 19 92, 263:H4 91- H496.62. Reid I: Role of vasopressin deficiency in the vasodilation ofseptic shock. Circulation 19 97, 95 :11 08 -11 10.63. Luk J: Role of V1 receptors ... blood flow and oxygen transport in septic shock. CritCare Med 19 93, 21: 1296 -13 03.97. Cowley AW, Monos E, Guyton AC: Interaction of vasopressin and the baroreceptor reflex system in the regulation...

Báo cáo y học: " Science review: Key inflammatory and stress pathways in critical illness – the central role of the Toll-like receptors" ppsx

... circulatory system, exitingonly when they are summoned by signals that emanate from the extravascular compartment. Other cells of the innateimmune system, including the macrophage and the dendriticcell, ... function.Immunity 19 98, 9 :14 3 -15 0. 41. Kawai T, Adachi O, Ogawa T, Takeda K, Akira S: Unresponsive-ness of MyD88-deficient mice to endotoxin. Immunity 19 99, 11 :11 5 -12 2.42. Whitmer JD, Koslovsky JS, Bahler ... widely observed in septic shock. In part, they do so bytriggering the release of many secondary cytokines, includ-ing IL-6, and numerous chemokines, which may further con-tribute to the septic...

Báo cáo y học: "Science review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance" docx

... blood lympho-cytes, monocytes, and neutrophils. Blood 19 94, 84 :12 01- 1208. 13 2. Thornberry NA, Lazebnik Y: Caspases: enemies within. Science 19 98, 2 81: 1 312 -13 16. 13 3. Takeda Y, Watanabe H, Yonehara ... 19 85, 4 :14 1 -15 6. 14 . Firrell JC, Lipowsky HH: Leukocyte margination and deforma-tion in mesenteric venules of rat. Am J Physiol 19 89, 256:H1667-H1674. 15 . Perry MA, Granger DN: Role of CD 11/ CD18 ... inflamma-tory lung neutrophils is associated with decreased expres-sion of interleukin -1 beta converting enzyme family proteases(caspases). Surgery 19 97, 12 2 :16 3 -17 1; discussion 17 1 -17 2. 17 3. Seely AJ,...

Báo cáo y học: "Science review: Extracellular acidosis and the immune response: clinical and physiologic implications" potx

... infusion of 0 .1 N HCl to reduce the SBE by5 10 and 10 15 mEq/l, respectively. We measured MAP,arterial blood gases, electrolytes, and plasma nitrate/nitritelevels at 0, 3, 6 and 8 hours. MAP ... Effects of oxygen tension and pH on the respiratory burst of human neutrophils. Blood 19 79, 53 :11 33 -11 39.29. Beachy JC, Weisman LE: Acute asphyxia affects neutrophilnumber and function in the rat. ... Kidney Int 19 95, 47 :15 37 -15 45. 16 . AlKharfy KM, Kellum JA, Matzke G: Unintended immunomodula-tion: part I. Effect of common clinical conditions on cytokinebiosynthesis. Shock 2000, 13 :333-345. 17 ....

Báo cáo y học: "Science review: Role of coagulation protease cascades in sepsis" ppt

... The ternary TF–VIIa–Xacomplex is the target for physiologic regulation by TFpathway inhibitor (TFPI), which simultaneously interacts withVIIa and Xa to form a stable quaternary TF–VIIa–Xa–TFPIcomplex ... (pericytes, cardiomyocytes, smoothmuscle cells, keratinocytes) and by vascular monocytes and endothelial cells upon induction by inflammatory cytokines orendotoxin [3]. TF is the high-affinity ... fromendothelial cells [49]. APC therapy may rescue the disabledAPC pathway in severe sepsis and restore anti-inflammatoryAPC–PAR1 signaling by utilizing residually expressed EPCR.Notably, blocking...

Báo cáo y học: "Science review: Mechanisms of ventilator-induced injury" pps

... Incidence and mortality after acute respi-ratory failure and acute respiratory distress syndrome inSweden, Denmark, and Iceland. The ARF Study Group. Am JRespir Crit Care Med 19 99, 15 9 :18 49 -18 61. 8. ... at5 15 /10 0,000 per year [ 6–9 ], but recent data suggest the incidence may be higher [10 ]. ARDS is a syndrome charac-terized by the formation of protein-rich pulmonary edema,hyaline membranes, and ... syndrome? Am J Respir Crit Care Med 20 01, 16 4: 17 01- 1 711 . 12 . Mead J, Takishima T, Leith D: Stress distribution in lungs: amodel of pulmonary elasticity. J Appl Physiol 19 70, 28:596-608. 13 ....

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