... orientation, and specificity of this
domain, with residues Tyr91 and Tyr137 forming
interaction pocket 1; Tyr93, Tyr137 and Trp119 form-
ing pocket 2, and the valley between n-Src and RT
loops included by ... into binding grooves 1 and 2 created by the n-Src
loop and the 3
10
helix, stabilized by stacking interac-
tions of the pyrrolidine ring of Pro7 with the aromati...
... purposes)
Rapamycin reverses hypoxia-induced thickening of the right ventricular wall and hypertrophy of individual cardiomyocytesFigure 6
Rapamycin reverses hypoxia-induced thickening of the right ventricular ... cardiomyo-
cytes of the left ventricular wall were unaffected by
changes in the oxygen supply. Hypoxia-induced hypertro-
phy of the right ventricle and o...
... feedback
system between TNFα and IL-32 promotes the tissue inflam-
mation in the synovium and the intestinal epithelium. In this
way, IL-32 has a close relationship with the proinflammatory
cytokines, ... detected in the synovial-infiltrated
lymphocytes. We supposed that IL-32-producing lym-
phocytes infiltrating the inflamed synovium participate in the
production...
... occurs late in the infection cycle, and plays
probably only a minor role in the potential success of
insect installation. The latter is probably strongly relying
on the dynamic balance between rapid ... largely from that induced by wounding
alone. The latter resulted mainly in a very limited sap-
wood drying very close to the wounds and almost no
resinosis. The prese...
... populations and/ or genetic markers. The latter
have the particular advantages of being present from the onset
of the disease and of remaining unchanged by therapy. To
date, the only genetic susceptibility ... early inflamma-
tory arthritis who were prospectively recruited between Octo-
ber 1998 and January 2002 in two French regions: the entire
province of Upper Normandy...
... confer their activation of the immune system mainly
in the lymph nodes, without leaving any signs of inflammation
in the exposed skin [11,25-28]. Here, an initial activation of the
innate immune system ... previously [16], all potential cases were examined
and diagnosed by a rheumatologist at the unit entering the
case into the study. All rheumatology units linked to the...
... association between the FPI
and some parameters of dynamic foot function. Inconsistent findings between the PFPS and control groups
indicate that pathology may play a role in the relationship between ... group.
Inconsistent findings between the PFPS and control
groupsindicatethatpathologymayplayaroleinthe
relationship between static foot posture and dynamic
functio...
... explanation for the discrepancy
between the in vitro and in vivo settings might be that
the intravenously injected MSCs do not reach the spleen
and ly mph nodes and are therefore unable to inhibit the
Figure ... immunized on day 0 with collagen type II (CII) in
complete Freund’s adjuvant and injected intravenously with MSCs on day 16 and day 23. The mean arthriti...
... designed the
investigation, and participated in the data collection, statistical analysis and
drafting of the manuscript.
Competing interests
The authors declare that they have no competing interests.
Received: ... with the present study. The patient:
control ratio in our study is 291:725, in the UK cohort
455:595 [14], in the German patient group 375:299 [15], in...