Báo cáo y học: "Perioperative optimization and right heart catheterization: what technique in which patient" pptx
Báo cáo y học: "Perioperative optimization and right heart catheterization: what technique in which patient" pptx
... guide therapy in patientswith severe sepsis and septic shock.We believe that this important study highlights again thatpulmonary artery catheters should not be inserted routinely in patients ... supply and demand, and it is particularly useful when large changes in oxygendemand are expected to occur (e.g. in anesthesia,hypothermia, pain, etc.). The monitoring of SvO2may alsolimit the ... agents,because high doses of inotropic agents may worsen thebalance between oxygen supply and demand even thoughcardiac output increases [10]. Oxygen extraction has alreadybeen used in various groups...
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Báo cáo y học: "Pro/con clinical debate: Hydroxyethylstarches should be avoided in septic patient" pptx
... greater volume of crystalloidmay be needed in comparison with 5% albumin [1].Maintaining COP by administration of HES could, in theory,reduce pulmonary oedema. One study including septicpatients ... variety of reasons you have decided you would like to givehim intravenous colloids. The only colloid available in yourintensive care unit is hydroxyethylstarch.CommentaryPro/con clinical ... of hydroxyethyl starch(HES) infusions. Acta Anaesthesiol Scand 2001, 45:686-689.11. Wilkes MM, Navickis RJ, Sibbald WJ: Albumin versus hydrox-yethyl starch in cardiopulmonary bypass surgery:...
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Tài liệu Báo cáo Y học: Regulated expression and intracellular localization of cystatin F in human U937 cells pptx
... containing three tandemlyrepeated type 2-like cystatin domains. Type 2 cystatinsidentified in higher animals include cystatins C, D, S, SA, and SN [2], but also the recently reported cystatin ... arereadily secreted in mammalian [20] and insect [5] cells,respectively. Cystatin F is an unusual type 2 cystatin in thatit is a glycoprotein [5,6], and it is known that many proteinsfound in intracellular ... N-glycosylationmotifs at positions 36–38 and 88–90 (cystatin C numbering).Recombinant cystatin F expressed in Sf9 insect cells isindeed glycosylated [5].Compared to other cystatins, cystatin...
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Báo cáo Y học: Processing, stability, and kinetic parameters of C5a peptidase from Streptococcus pyogenes pptx
... 1-trans-Epoxy-succinyl-leucylamido (4-guanidino) butane (E-64) and its analo-gues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem. J. 201, 189–198.15. Matsuka, Y. V., ... vivowith the intramolecular route dominating during periods ofminimum synthesis and secretion of the cysteine protease.The role of a heterologous intermolecular mechanism in theprocessing of C5a ... ofstreptococcal cysteine protease and analyzed by SDS/PAGE (Fig. 2B). Upon incubation, the band correspondingto C5a peptidase precursor steadily increased its mobility onSDS/PAGE resulting in the appearance...
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Báo cáo y học: "Aerobic exercise and its impact on musculoskeletal pain in older adults: a 14 year prospective, longitudinal study" doc
... micro-injury, psychologicallybased increase in pain threshold, innately high pain thresholdinfluencing decision to exercise vigorously, or other psycho-logical mechanisms.Musculoskeletal pain ... time. Aspain and disability are linked, our findings add to the evidencethat morbidity associated with aging can be reduced by partic-ipating in regular aerobic activity.Competing interestsThe ... pain.ConclusionThe primary finding from this investigation is that while paindoes increase with age in subjects in all study groups, therewas no progressive increase in musculoskeletal pain...
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Báo cáo y học: "PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease" ppsx
... from arginineinto tryptophan. This amino acid change disrupts the bindingof Lyp to an intracellular kinase, Csk, which can then no longerinactivate another kinase, Lck, that is involved in T-cell ... determined using enzyme-linkedimmunoassays. Genotyping was performed using an ABIPRISM 7900HT instrument and HLA-SE genes were identifiedusing PCR sequence-specific primers. The 1858T allele and also ... possibly by influencing the progression ofan overt autoimmune disease.Competing interestsThe authors declare that they have no competing interests.Authors' contributionsMJ was a main investigator...
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Báo cáo y học: "Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblast" potx
... MMPs,proinflammatory cytokines and chemokines [13].There is increasing evidence that SFs are key players in thepathogenesis of RA by invading and eroding hyaline cartilage.SFs, activated locally, ... growthfactor, insulin-like growth factor-binding proteins), morpho-gens, enzymes, numerous cytokines and chemokines, inter-leukins, and so forth [52]. It can be hypothesized that astringent control ... rather resulted from enzymerelease by cells (including infiltrating inflammatory cells) withinthe joints.Competing interestsThe authors declare that they have no competing interests.Authors'...
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Báo cáo y học: "Clade, Country and Region-specific HIV-1 Vaccines: Are they necessary" pptx
... of Microbiology and Immunology, University of Melbourne, Vic 3010, Australia and 6Department of Clinical and Biological Sciences, University of Insubria, Varese, 21100, ItalyEmail: Karen ... virusesaccording to geographical location. Today, due to contin-uous virus transmission, mutation and recombination,the demarcation of HIV-1 subtypes has become increas-ingly blurred, and the categorization ... Central yours — you keep the copyrightSubmit your manuscript here:http://www.biomedcentral.com/info/publishing_adv.aspBioMedcentralAIDS Research and Therapy 2005, 2:3 http://www.aidsrestherapy.com/content/2/1/3Page...
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Báo cáo y học: " Severe thrombocytosis and anemia associated with celiac disease in a young female patient: a case report" pdf
... thrombopoietin and erythropoie-tin might explain thrombocytosis in children with iron-deficiency anemia [8]. In our case, we observed a markedincrease in the level of erythropoietin which declined ... c-mpl and theerythropoietin receptor. On the other hand, it has beensuggested that erythropoietin and thrombopoietin cansynergistically stimulate megakaryocyte proliferationowing to signaling ... thrombocytosis• Chronic myeloproliferative disorders such as CML, PV, ET• Certain myelodysplastic syndromes such as 5q-syndrome• Underlying or occult malignancy• Chronic inflammatory or infectious...
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Báo cáo y học: "The expression and significance of protooncogene c-fos in viral myocarditis" pot
... calculated.Histopathological ExaminationOne section of the heart specimen was fixed in 10% for-malin, embedded in paraffin, stain ed with hematoxylin and eosin, and then observed by microscopy at 200 ×magnification. ... and cell infiltration were extensive on day 7,with necrotic areas appearing more prominent. Therewere many lymphocytes and macrophages in and around the necrotic foci. Infiltration of the inflammatorycells ... protein increased significantly at 3days after virus in oculation in VMC mice. The propor-tion of positive cardiomyocyte nucl eus and total cardi o-myocyte nucleus also increased apparently with...
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