Báo cáo y học: "The International Sepsis Forum’s controversies in sepsis: my initial vasopressor agent in septic shock is norepinephrine rather than dopamine" pot

... or registry information; with the intentof defining 'real world' experience [7-15].Disease severity and mortality rates tend to be higher in regis-tries or databases than in clinical ... havebeen registries for individual institutions or countries [7-15]. In all cases, including PROGRESS, there was higher diseaseseverity and mortality in comparison to severe sepsis clinicaltrials. ... Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis; SAPS II: Simplified Acute Physiology Score II; SIRS: Systemic Inflammatory Response Syndrome; SSC: Surviving Sepsis...

... Evaluative Research in Orthopaedic Surgery atthe University of Bern, Switzerland, allows online andoffline data entry. All information is sent in an encryptedfashion and in those cases where ... that is feasible in a research orientated butalso purely clinical setting; this because of the modularityhow data can be recorded. The consistent use of the sys-tem assures a stringent internal ... statistical frequency analyses andviewing of radiographs 24/7 from any computer withinternet connection. Since primary interventions, post-operative complications and revisions are clearly assign-able...

... awaited [62].Marcos Intraglietta (La Jolla, CA, USA) presented anemerging alternative hypothesis to the dogma of maintainingoxygen delivery by maintaining oxygen carrying capacity (i.e.RBC transfusion). ... simultaneously subjecting the lung to overdistensionand ventilator-induced lung injury. Finally, it was commentedthat the NIH PEEP trial had recently been abandoned since initial analysis had shown ... of the bactericidal/per-meability increasing protein and lipopolysaccharide bindingprotein in sepsis patients: gender-specific genetic predisposi-tion to sepsis. Crit Care Med 2001, 29:557-561.23....

... thehost response in sepsis is coordinated across multiplepathways including inflammation, coagulation, metabo-lism and tissue hypoxia. An important goal in sepsis research is to develop a more ... response.Using animal models of sepsis, we have recentlyshown tha t VEGF plays an important role in mediating sepsis pathophysiology [20]. The biological plausibilityof these findings is supported by ... showingthat sFlt-1 is increased in patients with sepsis and that it is a superior marker o f sepsis severity compared withthe other markers tested.Our findings add to the existing literature in...