... all the pro-apoptoticproteins, Bax, Bid, Bak and Bad, are up-regulated(Fig. 5) along with caspase-9 mRNA and protein, indi-cating the involvement of the intrinsic pathway in the H2O2-induced ... apoptosis wereassociated with changes in pro- ⁄ anti-apoptotic andother proteins, the expression of these proteins andtheir mRNAs were studied by western blotting andRT-PCR analysis, respectively. ... explored.Following the binding of FasL with Fas, activation of caspase-8 occurs, ensuring the direct activation of cas-pase-3 [8,19]. The present findings depicted a markedrise in caspase-8 transcripts,...