... 6065MINIREVIEWMarine toxins and the cytoskeleton: okadaic acid and dinophysistoxinsCarmen Vale and Luis M. BotanaDepartamento de Farmacologı´ a, Facultad de Veterinaria, USC, Lugo, SpainIntroduction The ... 926–934.19 Yano Y, Sakon M, Kambayashi J, Kawasaki T, SendaT, Tanaka K, Yamada F & Shibata N (1995) Cytoskel-etal reorganization of human platelets induced by the protein phosphatase 1 ⁄ 2 A inhibitors ... loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization due to an alteration in the tyrosine-phosphory-lated state of the focal adhesion kinases and paxillin....