Báo cáo y học: " Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment" pot
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Research
Alveolar macrophage-epithelial cell interaction following exposure
to atmospheric particles induces the release of mediators involved
in monocyte mobilization and recruitment
Hiroshi ... epithelial cells (HBEC)
enhances the synthesis and release of a variety of pro-
inflammatory cytokines and that supernatants from these
co-cul...
... carried out the establishing the
cell lines and the functional analysis of the cell lines. MO,
FG, and MF participated in the experimental design, data
interpretation, and the writing of the manuscript.
Acknowledgements
We ... Tanaka Y, Gejyo F, Fujii
M: PDZ domain-binding motif of human T -cell leukemia
virus type 1 Tax oncoprotein is essential for the int...
... clues to the mechanism underlying protein
stability at the amino-acid level. The molecular mechanisms
underlying protein maturation, folding, and stability in
bacterial cytochromes c are beginning ... have gained insight into the molecular
mechanisms underlying cytochrome c maturation and
folding as well as stability. Bacterial cytochrome c has
contributed greatly to our und...
... in RA synoviocytes
T cells and monocytes are two major cell types involved in
RA pathogenesis. Some of their derived cytokines may be
present at very low concentrations in the RA joint, and
their ... membrane
with monocytes/T cells, by the proliferation of synovial lining
cells and by the production of proinflammatory cytokines,
which contribute to cartilage and...
... scaffold to bring the
two B progenitor cells into close proximity of the T cell to allow
cytokine eavesdropping.
The model outlined in Fig. 7 bears some resemblance to other
published models of spreading ... (sIg) binds to and processes the determinant
and displays the resulting epitopes to T cells in the context of
MHC II and accessory proteins in a...
... 3b).
As inflammatory cytokines are thought to play a critical role in
the pathogenesis of RA, we monitored the production of the
proinfammatory cytokines TNF-α, IL-1β, and INF-γ as well as
anti-inflammatory ... and INF-γ from
isolated spleen cells induced by LPS. As the involvement of
each of these cytokines in the pathogenesis of arthritis is well
Figure 5
Stead...
... of the innate immune system
as their cardinal feature. While the intracellular functions of
alarmins vary, in their extracellular form, they function as pro-
inflammatory mediators to alert the ... functions in vivo to enhance inflammation by
binding PAMPs, DAMPs, and cytokines to promote dual-
receptor interactions that may be especially effective because
of their p...
... National Institute of Allergy and
Infectious Diseases (NIAID) due to its ability to initiate infec-
tion via aerosol contact; the rapid onset of sepsis following the
development of symptoms and the ... lineage,
together with under expression of transcripts related to T-
cells, B-cells, and cytotoxic cells, indicated substantial dys-
regulation of the host immun...
... studies,
and performed the Western blotting analysis. YJL and ICC participated in the
interpretation of data and performed the statistical analysis. JCY conceived
of the study, designed and coordinated ... previously [12]. In brief, a
bolus intraveno us injection of phenylephrine (10 μg/kg)
was administered to evoke the BRR before and 10, 30 or
60 min after mic...
... of PVL of only 2.3% and Qicai [5] surprisingly
0%. The advantages of the semicontinuous suture t ech-
nique may consist in a shorter CPB, in a reduced myo-
cardial ischemic injury time, and in ... non coronary aortic sinus, due to the
semicontinuous suture breaking (Figure 2). The other
two sutures of the left and right coronary sinuses were
intact. After the...