... patient. Hayes andCommentaryThe International Sepsis Forum’s frontiers in sepsis: high cardiacoutput should be maintained in severe sepsis Jean-Louis VincentHead, Department of Intensive Care, ... 4 VincentIntroduction Sepsis is associated with systemic, mediator-inducedalterations in oxygen utilization, including increased oxygendemand, altered oxygen extraction, and decreasedmyocardial ... SvO2monitoring is useless in sepsis or septic shockbecause, in sepsis, SvO2may be normal or high despiteregional tissue hypoxia, because of altered tissue oxygenextraction. However, clinical...