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Báo cáo y học: "What are the challenges of translating positive trial results in severe sepsis into clinical practice" pptx

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Báo cáo y học: "What are the challenges of translating positive trial results in severe sepsis into clinical practice" pptx

... criteria for sepsis in clinical practice or therapeutic trials. The panel went on to discuss what elements should beincluded in the definition of sepsis. Perhaps unsurprisingly,they essentially recreated ... study of rhAPC in severe sepsis, Bakker and colleagues actively considerwhether each patient fulfils the criteria for entry into the study; in short, there is more of a reason to make an earlydiagnosis ... diminish the potential impact of adopting novel therapies/strategies in the treatment of thiscommon and serious syndrome.Conclusion The confusing terminology and woolly definitionssurrounding...
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Báo cáo y học: "What determines the evolution of early undifferentiated arthritis and rheumatoid arthritis? An update from the Norfolk Arthritis Register" ppt

... evidence of anyinflammatory activity in their joints while they are off treatment.Persistence is the opposite of remission. There are problems in the literature regarding the definition of remission ... affect the severity of the disease and genes that affect the handling of the drug.Then there are psychosocial factors such as adherence toand expectations of therapy outcome. Finally, there are aspects ... [24].Non-Hodgkin’s lymphomaAlthough there was no evidence of any overall increased risk of cancer in the early years of IP and RA in NOAR, there wasa definite increased risk of developing non-Hodgkin’slymphoma...
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Báo cáo y học: "What does the marriage of Open Access with online publication bring" docx

... excellent print journals dedicated toHIV-1 and the disease caused by it, AIDS. Many of them are now accessible online. However, we are launching the first Open Access journal in the AIDS arena – ... weeks, and the Section Editor will then make adecision based on these reports. This is to insure timelypublication of findings that are important in the preven-tion and cure of AIDS. Indeed, ... improving the quality of the journal. Consequently, the Editorial Board of the journal will constantly seek new ideas to improve the journal to serve as an excellent resource in AIDS researchand therapy...
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Báo cáo y học: "What is the role of surfactant and inhaled nitric oxide in lung transplantation" pps

... programmes use iNO routinely during earlyreperfusion of the lung. Bearing in mind that the concept of ischaemia/reperfusion injury in clinical transplantation alsoembodies the state of the donor ... role of surfactant in management of initially impaired graft functionafter lung transplantation, and do these findings apply toother forms of lung injury?Ischaemia/reperfusion injury leading ... plasma protein leakage into the alveolar space. In 1995 we were the first to report successful clinical treatment of reperfusion injury in a lung transplantrecipient by administration of exogenous...
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Báo cáo y học: "What is the clinical and ethical importance of incidental abnormalities found by knee MRI" docx

... read the MRI scans: they are not usually trained in musculoskeletal radiology or MRI beyond the measurements they perform. The researcher is obliged toput the health of the participant above the ... with the ongoingmanagement of these incidental lesions at many levels, incor-porating clinical, ethical, and financial aspects. Whilst, basedon these data, the prevalence of clinically important ... facilitate the institution of an appropriate system.Although the frequency of these lesions is low, they may have clinical significance and may be the first sign of life-threateningdisease....
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Báo cáo y học: "What is the best site for central venous catheter insertion in critically ill patients" doc

... into the pleural cavity.Consequently, the subclavian vein is generally thought to be the least suitable approach to the central circulation in patientswho are on anticoagulant therapy. In the ... at increased risk for pulmonary complications (severe emphysema, acute respiratory distress syndrome)were not included in the analysis – a fact that may explainthis surprising finding. In a ... was observed with internal jugular catheterinsertion [3]. Finally, in a recent prospective cohort study notincluded in the meta-analysis by Ruesch and coworkers, the rate of tip malposition...
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Báo cáo y học: "What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?" ppsx

... Beclin-1 possesses a BH3 domain that interacts with the BH3 receptor domain of the anti-apoptotic proteins of the Bcl-2 family. BH3-only proteins can induce autophagyby competitively disrupting ... Tatfolding or the native Rev folding for the second study mayexplain the absence of protection. More puzzling, how-ever, are the results of two other studies using similar viralvectors expressing ... mightexplain the lack of efficacy of the Tat vectored vaccine in the second study [105]. The second study resembled moreclosely reality since a vaccinated person would not likelybe exposed...
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Báo cáo y học: " Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice

... the gastrointestinal tissues from the cytotoxicity of CY in mice. We also profiled the changes of the expression of growth factors in gastric tissues in response to the damage by CY and protection ... always clinically necessary in cancer patients receiving chemotherapy, so as to allow their immune systems to restore function [2]. On the other hand, the death of GI cells breaks down the physical ... protective effect of AP on CY-induced cytotoxicities in both the hemopoietic and gastrointestinal tissues was undefined. Any of these actions would extend the therapeutic application of CY in cancer...
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Báo cáo y học: "Update on the treatment of ocular toxoplasmosis"

... their efficacy in vivo in the treatment of toxoplamosis. To increase the efficacy of therapy a combination of sulfadiazine and pyrimethamine was proposed since synergistic effect of these two drugs ... survey of the opinion of oph-thalmic specialists in uveitis was performed recently by Gary Holland. [3] The reasons that were commonly accepted to introduce a therapy were the following: a) the ... by Rothova et al was 250mg a day or 500mg every other day and therapy was associated with pyrimethamine 100mg on the first day that was fol-lowed by 50mg a day. Prophylaxy of recurrence of...
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