... new or
ongoing infection. You wonder whether steroids might help
facilitate his recovery.
Commentary
Pro/con clinical debate: Are steroids useful in the management
of patients with septic shock?
Frank ... Walley
The debate surrounding the use of corticosteroids in septic
patients has continued for over 30 years. Two meta-
analyses in the mid-1990s see...
... vein
resulting in disruption of the endothelial-intercellular
junctions and seepage of the drug into the interstitial
space [1]. Extravasation of the highly albumin-bound (70-
90%) phenytoin increases the ... the advantage of
blocking the sympathetic innervation of the upper limb,
thus improving the perfusion and relieving the ischaemic
pain associated with v...
... have identified an increase in proteolytic activity within the
glomerulus coinciding with the development of proteinuria in the
(NXB×NZW)F
1
mouse model of systemic lupus erythematosus.
Here we ... with evidence of central nervous system
involvement. There are reports indicating a central role for
MMPs in increasing permeability of the blood-brain barrier in
infl...
... quantities of Vpr. 2). Vpr promotes the binding of the PIC (including MA, integrase (IN) and proviral DNA) to importins and
nucleoporins, thereby facilitating nuclear entry of HIV-1 provirus into the ... found in brains of patients suffering
from HIV-D [155]. The presence of TNF-a protein and
mRNA in patients with HIV-D has been reported to sig-
nificantly correlat...
... haemody-
namic instability (five patients) , one refusal to continue in the
study and nine complications were related to the ventilator and
the automatic mode of weaning. In six of the patients, the ... during
the weaning process. In some, instead of the pressure support
decreasing gradually, it increased for a while and then
decreased until the point of extuba...
... spine pain [11]
Definition of non specific Thoracic spine pain
Midline back pain – for the purposes of this trial, the pain will be bound by the lateral margins of the thorax laterally and the ... the person requesting the randomisation has
confirmed that they wish to proceed with entry into the
trial. The participants will be analysed in the groups to
which they...
... (V
A
/Q) areas,
indicating sustained derecruitment of the lungs. This
phenomenon has also been demonstrated in the clinical
setting by Richard and colleagues [7] in ARDS patients while
reducing the ... the concept of
setting PEEP according to a table becomes evident, and in
the present study, what is very probably a ‘false’ PEEP
reduction (obviously triggered by the...
... study
investigating ‘opinions about food’ in the Denver Metro
and Northern Colorado areas. No further information
regarding the purpose of the study was given. Indivi-
duals were excluded if they had a visual ... level of fullness
and interactions where included in the repeated mea-
sures analyses of vari ance model when testing the effect
of portion size on ratings. In...
... no
obvious signs of infection, you wonder whether antibiotics
are useful in the patient’s management.
Review
Pro/con clinical debate: Antibiotics are important in the
management of patients with pancreatitis ... attractive as it may allow
the use of prophylaxis without the risk of inducing superinfec-
tions through the use of long-term broad-spectrum...
... positioning.
Commentary
Pro/con clinical debate: The use of prone positioning in the
management of patients with acute respiratory distress
syndrome
John J Marini* and Gordon Rubenfeld
†
*Professor of ... feel
obliged to offer some therapy, any therapy, to a patient in
imminent danger of dying [16].
As is often the case in critical care, a therapy that looks grea...