Báo cáo y học: "Practising evidence-based medicine: the design and implementation of a multidisciplinary team-driven extubation protocol" pptx
Báo cáo y học: "Practising evidence-based medicine: the design and implementation of a multidisciplinary team-driven extubation protocol" pptx
... potentially accelerate decision-making withregard to extubation; and to assess the safety and feasibility of our approach.Materials and method The intervention was carried out in a 14-bed medical/surgicalICU ... team members were recorded. Data on duration of MV,duration of ICU stay and the rate of reintubation were collected.Safety The MDT agreed that, in order to provide and ascertain safety of the ... protocol was regularly re-evaluated and updated. Nurses and RCPs responded favourably to the MDT-driven extuba-tion protocol because it provided greater autonomy to the staff and apparent earlier extubation...
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Báo cáo hóa học: " Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial" pot
... safety and monitoringSafety considerationsIn a large randomized trial of intravenous albuterol (sal-butamol) in acute lung injury, the primary side effectswere tachycardia and cardiac arrhythmias ... donation awareness,family consent, clinical management, and organ utiliza-tion, there rem ains a persistent shortage of organs fortransplantation [1] and a plateau in the number of organ donors ... hours.Subjects are prospectively randomized in a 1:1 ratioamong study and placebo groups. Randomization is con-ducted by the UCSF Investigational Pharmacy. The Investigational Pharmacy prepares study drug...
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Báo cáo y học: "Autoantibody profiling for the study and treatment of autoimmune disease" docx
... cleaved and the eTAG™ is released.Mixtures of eTAGs™ are readily separated and analyzed bycapillary electrophoresis.Arrays of addressable nanoparticlesSurroMed (Mountain View, California, USA) ... plaque-based and colony-basedassays are further limited by incomplete addressability;DNA sequence analysis is required to determine the identity of the antigens at each location on the array.Ekins ... and to serve as spacersbetween antigens and the surface, particle, or tag. Bead and tag systems are currently limited by the relatively smallnumbers of addressable elements available.Autoantibody...
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Báo cáo y học: " New approaches in the diagnosis and treatment of latent tuberculosis infection" pptx
... apoptosis of macro-phages via the caspase -dependent pathway and cytolysis of type 1 and type 2 alveolar epithelial cells and helps in the dissemination of M. tuberculosis [20,70]. The released bacilli ... tuberculosis across a bilayer of epithelial and endothelial cells as a model of the alveolar wall is a consequence of transport within mononuclear phagocytes and invasion of alveolarepithelial cells. ... Nat Rev Microbiol2010, 8:296-307.27. Ishikawa E, Ishikawa T, Morita YS, Toyonaga K, Yamada H, Takeuchi O,Kinoshita T, Akira S, Yoshikai Y, Yamasaki S: Direct recognition of the mycobacterial...
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Báo cáo y học: "Sepsis-associated delirium: the pro and con of C5a blockade" ppsx
... Indeed, byincreasing the BBB permeability, C 5a may ease pathogen-associated molecular pattern access to brain sensing areassuch as paraventricular and amygdala cells. Upregulation of C 5a therefore ... therefore allows the stress system to mount anappropriate response. This assumption is supported by atleast three major facts. Firstly, blockade of C 5a markedlyreduced the activation of the hypothalamic–pituitary ... locuscoeruleus/noradrenergic system are tightly interconnected toorchestrate homeostasis in stress. These structures are allbehind the BBB. The circulating inflammatory mediators mayreach these brain areas...
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Báo cáo y học: " Tracheostomy patients on the ward: multiple benefits from a multidisciplinary team" pps
... such as hydration, humidifi cation of airway, and suctioning of secretions9. Factors leading to inadvertent decannulation (such as underlying mental status) and the best way of securing tracheostomy ... multifaceted care of these diffi cult patients to minimize length of stay and complications once the patient leaves the ICU.As reported in the previous issue of Critical Care, Garrubba and colleagues ... tracheostomy patients, there are multiple variables that may impact clinical outcome, complica-tions, or length of stay or all three. Some of these considerations are the following:1. Early versus...
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Tài liệu Báo cáo Y học: Dinucleoside polyphosphates stimulate the primer independent synthesis of poly(A) catalyzed by yeast poly(A) polymerase ppt
... polyadenylationfactor [4,5]. The core yeast poly (A) polymerase appears tohave a molecular mass of around 63 kDa [3]. Separatedform the complex, the core yeast enzyme catalyzes the addition of poly (A) tails ... adenylylation of thesecompounds and the absence of synthesis of poly (A) by the E.colipoly (A) polymerase, we did not observed adenyly-lation of guanosine, GDP or Gp4G by the yeast enzyme.In the ... doi:10.1046/j.1432-1033.2002.03253.xRelative activity of GpnGs as effectors of the synthesis of poly (A) Based on the above results, the effect of several diguanosinepolyphosphates on the synthesis of poly (A) was comparat-ively...
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Báo cáo Y học: Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant doc
... 0 .2 A ˚away and the O10 of the benzoaxine-2-one ring 0.3 A ˚towards the N103 amide. These subtle changes are accompanied byrepositioning of the side chain of V179 0.4 A ˚towards and of D192 ... charged and linear lysine for a uncharged and branched asparagineat position 103 result in a drastic change in the chemicalenvironment in the proximity of the mutation. This hasmainly two consequences ... good activity against the K103N mutant would beexpected to have favorable interactions with the mutantasparagines side chain, thereby compensating for resistancecaused by stabilization of the...
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Báo cáo Y học: Structural studies on the core and the O-polysaccharide repeating unit of Pseudomonas aeruginosa immunotype 1 lipopolysaccharide pot
... 2-acet-amido-3-O-acetyl-2-deoxygalacturonamide, 2-formamido-2-deoxygalacturonamide, 2-acetamido-2,6-dideoxyglucose and 2-(L-alanylamino)-2-deoxygalactose, respectively; allsugars are in the pyranose form and have the Dconfigurationunless ... (a or b)andthesiteofattachmentofQuiNActoRha(atposition2or3)aswellaswithO-acetylation and amidation of the GalNA derivatives(Table 3). Because O-acetylation and amidation, which arenonstoichiometric, ... elucidation of the core phosphorylation pattern, the O-polysaccharide biolo-gical repeating unit, and the site and the mode of the attachment of the O-polysaccharide to the core.MATERIALS AND METHODSBacterium...
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