... the design of the study, performed the statisticalanalyses, and revised the manuscript. TT and JK conducted the clinicalstudies, were involved in study design, contributed to interpreting the results ... Karagianis, Treuer, and Hoffmann and Mr. Case are full-timeemployees and minor stockholders of Eli Lilly and Company and/ or any of its subsidiaries.Received: 22 February 2010 Accepted: 14 September ... 8 of 9to have already gained at least 5 kg or 1 unit of bodymass index (BMI) before rando mization; therefore, mostappetite increase probably occurred before the studystarted, especially...