Báo cáo y học: " Biphasic effect of extracellular ATP on human and rat airways is due to multiple P2 purinoceptor activation" ppsx
Báo cáo y học: " Biphasic effect of extracellular ATP on human and rat airways is due to multiple P2 purinoceptor activation" ppsx
... of ATP on rat and human isolated airways ATP induced a fast and transient contraction of rat iso-lated airway rings which amplitude depended on the con-centration of agonist and the location ... delayed the return to baseline in extrapulmonary airways. Conclusion: Extracellular ATP induces a transient contractile response in human and rat airways, mainly due to P2X receptors and extracellular ... purposes)Respiratory ResearchOpen AccessResearch Biphasic effect of extracellular ATP on human and rat airways is due to multiple P2 purinoceptor activationBoutchi Mounkaïla, Roger Marthan and Etienne...
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Báo cáo y học: " Different effects of deep inspirations on central and peripheral airways in healthy and allergen-challenged mice" ppt
... mice is entirely due to exaggerated closure of peripheral airways and that excessive narrowing is due to purely geometricreasons.Inflammation of distal airways and lung parenchymadirectly affects ... sig-nificant effect on both tissue damping and tissueelastance.ConclusionIn summary, we have found that presence of DI may bluntbronchoconstriction of central airways in healthy mice and in acute ... airway resistance, to have bron-choprotective effects in healthy subjects, and to reversebronchoconstriction [3-8]. The effectiveness of a deepinspiration is related to the number of DI before...
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Báo cáo y học: "The effect of tight glycaemic control, during and after cardiac surgery, on patient mortality and morbidity: A systematic review and meta-analysis" pptx
... heterogeneityI2= 58%, p = 0.09) (Figure 6).Discussion To our knowledge, this is the first systematic review and meta-analysis conducted solely on the effects of tight and c onventional glycaemic control ... insulin administration may protect theheart in ischaemic conditions by increasing glucoseuptake by myocytes, increasing glycogenesis and redu-cing the concentration of free fatty acids [36,37].Limitations ... the pro-inflammatory effect of hyperglycaemia which may contribute to post-operative capillary leak syndrome, platelet dysfunction and a higher risk of post-operative complications[34,35]; (...
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Báo cáo y học: "The effect of substance P on asthmatic rat airway smooth muscle cell proliferation, migration, and cytoplasmic calcium concentration in vitro" pdf
... proliferate, migrate, and contract due to a variety of cytokines and inflammatory media-tors, especially in asthma airway remodeling.IL-13 is an important Th2 lymphocyte proinflamma-tory factor ... important effector cells in asthma. Increases in ASMC proliferation,migration, and cytoplasmic Ca2+concentration are critical to airway remodeling and hyper-responsiveness. Theeffects of substance ... cell proliferation, migration, and cytoplasmic calcium concentration in vitroMiao Li, Yun-Xiao Shang*, Bing Wei and Yun-Gang YangAbstractAirway remodeling and airway hyper-responsiveness are...
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Báo cáo y học: "The effect of substance P on asthmatic rat airway smooth muscle cell proliferation, migration, and cytoplasmic calcium concentration in vitro" potx
... proliferation, migration, and cytoplasmiccalcium concentration in vitro. Journal of Inflammation 2011 8:18.Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online ... 8:18http://www.journal-inflammation.com/content/8/1/18Page 8 of 9RESEARCH Open AccessThe effect of substance P on asthmatic rat airwaysmooth muscle cell proliferation, migration, and cytoplasmic calcium concentration in vitroMiao Li, Yun-Xiao ... antagonist WIN62577 could decrease ASMC calciumconcentration and inhibit ASMC proliferation and migra-tion, and therefore may be useful to alleviate asthma air-way remodeling and airway hyper-responsiveness.AcknowledgementsThis...
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Báo cáo y học: "Inhibitory effect of IL-8 on insulin action in human adipocytes via MAP kinase pathway." doc
... http://www.journal-inflammation.com/content/6/1/25Page 4 of 6(page number not for citation purposes) Effect of IL-8 on phosphorylation of Akt in human adipocytesFigure 2 Effect of IL-8 on phosphorylation of Akt in human ... insulinresistance and increased risk for coronary heart disease[5]. Tumor necrosis factor-α (TNF-α) is also elevated inobesity and may contribute to many aspects of adipose tis-sue biology including ... thatinflammatory stimulations may create a vicious circle of IL-8 production in human adipocytes via ERK pathway and/ or p38 MAPK pathway.In the initiation and maintenance of inflammatory reac-tions...
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Báo cáo y học: "The effect of CpG-ODN on antigen presenting cells of the foal" ppt
... lymphocyte reaction and the secretion of Th1 cytokines by T cells [20].In contrast to adults, human neonates have demonstratedimpaired response to multiple PAMPS, which may signif-icantly ... 5 days of life, and monthly up to 3 months of life. One of the foals was euth-anized due to septic synovitis and was removed from thestudy. An equivalent amount of blood was collected oncefrom ... co-stimulatory molecules and activation of T cells.Those effects were not observed in our data. LPS inflam-matory stimulation involves both common and differentpathways to CpG-ODN, and distinct cytokine...
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Báo cáo y học: " The effect of interleukin-13 (IL-13) and interferon-g (IFN-g) on expression of surfactant proteins in adult human alveolar type II cells in vitro" docx
... [22,28-33]. SP-D is an importantcomponent of innate immunity in the l ungs [1].Although it is difficult to explain the pathogenesis of lung diseases due to the dysregulation of only one cyto-kine, ... of bleomycin [21].IL-13 is a pleiotropic cytokine and a major effectormolecule at sites of Th2 inflammation and tissue remo-deling. IL-13 is a potent stimulator of eosinophilic, lym-phocytic, and ... for multiple comparison.Statistical significance was set at p < 0.05.Ito and Mason Respiratory Research 2010, 11:157http://respiratory-research.com/content/11/1/157Page 3 of 13(Additional...
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Báo cáo y học: "The effect of tiotropium therapy on markers of elastin degradation in COPD" doc
... anti-inflam-matory effect of the therapy. This anti-inflammatory effect could occur from several mechanisms.Improved clearance of bronchial secretions could occurconsistently with decreased airway obstruction, ... acetylcholine may have effects on inflammatory medi-ators and smooth muscle growth factors. Such effects maybe reflected in lung matrix injury with respect to elastindegradation [10,11]. This study examines ... presentonly in mature elastin. Changes in their concentration in body fluids indicate changes in elastindegradation and can be a reflection of tissue elastase activity. This study was undertaken to determine...
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Báo cáo y học: "The effect of antimicrobial resistance on patient outcomes: importance of proper evaluation of appropriate therapy" pps
... divorced from consideration of the effect of the therapy received. In addition to assessing delayin institution of therapy, analysis of the effect of appropriate-ness of therapy must take into account ... meta-analysis, have demonstrated such a difference [7]. Yet in theabsence of data to distinguish between therapy that is clinically appropriate and therapy that is microbiologicallysound but ... but clinically problematic, the effect on mortality of delay in receiving truly appropriate therapy, and the potentialimpact of this delay on the results of the multivariableanalysis, remain...
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