... of the immunoglobulin
superfamily which is activated by a variety of proinflammatory
ligands, including HMGB1, advanced glycated endproducts,
members of S100 proteins, and amyloid beta-peptide ... alarmins is therefore their translocation from
the inside to the outside of the cell [1].
During the past decade, studies in both patients and animal
models have establishe...
... contributions
HP and NM collected the data and drafted the manuscript. HP and JL
contributed to the treatment of the patient. LY and OL participated in
critical revision of the report and helped draft the ... 0.76
0
0.2
0.4
0.6
0.8
1
1.2
1.4
1.6
1.8
CREATININE mg/dl
DAY OF ADMISSION
SERUM CREATININE TREND DURING COURSE OF ADMISSION
Creatinine mg/dl
Upper Limi...
... Eleven
cycles of model building and refinement resulted in an R-
factor of 23.1%. and R
free
of 29.8% In the last cycle, 125
molecules of water were added and the R-factors dropped to
20.3 and 27.3%, ... stereochemical quality of the final model of the HsPII
protein was verified by
PROCHECK
[19]. The coordinates were
deposited in the Protein Data Bank as...
... chondrocytes treated
with azacytidine, reduced Smad2 and Smad3 expression
and signaling and increased Smad1/5 expression
correlated with elevated synthesis of type X collagen and
alkaline ... the degradation of Smad1/5/8 while Smurf2 stimulates mainly the degradation
of Smad2/3 [103]. Mitogen-activated protein kinases (MAPKs) modulate the stability and degradation...
... parameters and the ILD disease severity score and by
the finding that the deceased children with the most
severe course of disease exhibited the highest BALF levels
of these markers. The possibility that ... the patients
Children attending the Department of Pulmonology and
Allergology of the University Children's Hospital of
Munich during 1999–2004 wer...
... circulatory failure unexplained by other causes
(>2 points in SOFA score for the cardiovascular system).
The patients included in this study did not receive
low-dose hydrocortisone therapy as routine ... **P < 0.01.
Table 3 Correlations of sFas and IL-6 levels with the
organ dysfunction scoring systems
a
SOFA MODS
Protein Day 1 Day 5 Day 9 Day 1 Day 5 Day 9
sFas
Nonsepsi...
... human double-stranded RNA acti-
vated protein kinase induced by interferon. Cell 62, 379–390.
2. Hovanessian, A.G. (1989) The double stranded RNA-activated
protein kinase induced by interferon: dsRNA-PK. ... (2000)
Activation of p38 mitogen-activated protein kinase and
c-Jun NH
2
-terminal kinase by double-stranded RNA and en-
cephalomyocarditis virus: involvement of RNase L,...
... aminoguanidine) and ROS
inhibitors (apocynin and allopurinol) markedly reduced
endothelial disruption in this in vitro model. Since we also
found that SIN-1 was highly effective in inducing dose
dependent ... help
conceptualize the study, participated in its design and coordination,
interpreted the data and critically shaped the manuscript draft. All authors
read and a...
... the bodybuilders showed intakes of protein of
34% of total calories [10].
If dietary protein and overall calorie intake are inade-
quate, body proteins will be broken down to meet the
body’ s ... infor-
mation of metabolic responses to high protein intake in
bodybuilders. Further studies would be required to
determine the effects of the intensity of exercise and...
... been reported by us and
others, while the synergistic effects of HMGB1 and IL-1a
are described for the first time in this study.
So, in addition to the direct cytokine-inducing effects of
HMGB1 ... signalling for
induction of cytokine production
HMGB1 has been demonstrated to interact with TLR4
and thereby to induce cytokine production [13,46].
Although the HMGB1 used...