Báo cáo y học: "Hormonal regulation of alveolarization: structure-function correlation" ppt
Báo cáo y học: "Hormonal regulation of alveolarization: structure-function correlation" ppt
... University of Pennsylvania School of Medicine, Philadelphia, PA, USA and 3Division of Neonatal-Perinatal Medicine, Division of Pulmonary and Vascular Biology, Room K4.224, University of Texas ... signifi-cant cause of morbidity and mortality affecting as many as30–40% of infants born less than 30 weeks gestation [1].While the pathophysiology of BPD includes both inflam-matory and fibrotic ... either saline or Dex SQ daily on days 1–14 followedby either IP CSO or RA daily on days 24–36: (1) EarlySaline + Later CSO; (2) Early Saline + Later RA; (3) EarlyDex + Later CSO; (4) Later...
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Báo cáo Y học: Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells pdf
... aim ofthis studywas tocharacterize the role of an acyl-CoA thioesterase (ARTISt)and an acyl-CoA synthetase as members of an alternativepathway in the regulation of the intracellular levels of ... activity in Y1 cells. This points to a direct effect of ACTH upon enzyme activity. However, we cannot ruleout a possible activation of the enzyme by an ACTH-mediated increased availability of its ... currentlynot known. The high degree of sequence similarity betweenthe CTE-I and MTE-I genes suggests that they divergedrelatively recently by gene duplication, possibly by duplica-tion of an...
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Báo cáo Y học: Differential regulation of the Fe-hydrogenase during anaerobic adaptation in the green alga Chlamydomonas reinhardtii pot
... stress by redirect-ing t he synthetic machinery towards the synthesis of s omeenzymes involved in glycolysis or sugar-phosphatemetabolism [54].HydA belongs to a new class of Fe-hydrogenasesHydA ... they often catalyze the reduction of pr otons with a high specific activity to yield hydrogen[16]. Interestingly, Fe-hydrogenases were not found incyanobacteria, the free-living ancestor of ... Fe-hydrogenasesHydA of C. reinhardtii, the first isolated gene encodinga hydrogenase of a photosynthetic eukaryotic cell, repre-sents a novel type of Fe-hydrogenases. Parts of thededuced amino-acid sequence of...
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Báo cáo Y học: Transcriptional regulation of erythropoiesis Fine tuning of combinatorial multi-domain elements ppt
... differen-tiation in erythroid progenitors. Polycytemia vera is a clonalmyeloproliferative disorder, leading to hyperproliferation of erythroid, myeloid and megakaryocytic cells. Sixty percent of polycytemia ... survival of early hematopoietic cells, at the expense of differenti-ation.The proto-oncogene c-Mybc-Myb is abundantly expressed in immature hematopoieticcells of erythroid, myeloid and lymphoid ... structure of many of these factors variegatethe complex regulation of erythropoiesis.ACKNOWLEDGEMENTSChava Perry MD, is the incumbent of a basic research fellowship fromthe Israel Ministry of Health....
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Báo cáo Y học: Differential regulation of telomerase activity by six telomerase subunits potx
... telomeraseactivity was measured by TRAP/EIA cells 3 days later. (C) Telomeraseactivity after introduction of antisense oligonucleotides into PHA-stimulated lymphocytes. Ficoll-Hypaque isolated lymphocytes ... inhibition of TEP1 function by high concentra-tions of antisense oligonucleotides, telomerase activity wasdramatically diminished. Alternatively, hTR and hTERTmay play a minimal catalytic activity ... assembly of other telomerase subunits may amplify theenzyme function. In this scenario, deletion of mTEP1 inembryonic stem cells would have no effect on telomeraseactivity, and the level may be...
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Báo cáo y học: "Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factor" ppt
... Brinck-erhoff CE: A synthetic triterpenoid selectively inhibits theinduction of matrix metalloproteinases 1 and 13 by inflamma-tory cytokines. Arthritis Rheum 2001, 44:1096-1104.64. Suh N, Wang Y, ... ininflammatory arthritis. J Clin Invest 2000, 105:1799-1806.Arthritis Research Vol 4 No 3 Vincenti and Brinckerhoffto the transcription of an array of inflammatory genes, theirdirect regulation of MMP ... primaryrabbit synovial fibroblasts, only IL-1 is capable of inducingMMP-1 transcription [29]. This is due, in part, to the inabil-ity of TNF to activate the ERK pathways in these cells,both of...
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Báo cáo y học: "Negative regulation of cytokine signaling and immune responses by SOCS proteins" potx
... to bind to Tyr757 of gp130, Tyr985 of the leptin receptor and Tyr401 of the erythropoietinreceptor, Tyr729 of the granulocyte colony-stimulating factor(G-CSF) receptor, Tyr800 of the IL-12 ... 279:54708-54715.66. Ryo A, Suizu F, Yoshida Y, Perrem K, Liou YC, Wulf G, RottapelR, Yamaoka S, Lu KP: Regulation of NF-kappaB signaling byPin1-dependent prolyl isomerization and ubiquitin-mediatedproteolysis ... Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia. Int JCancer 2004, 112:846-853.86. Oshimo Y, Kuraoka K, Nakayama H, Kitadai Y, Yoshida K,Chayama K, Yasui...
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Báo cáo y học: "Immune regulation of bone loss by Th17 cells" doc
... Jr, Yarboro CH, Arayssi TK, Pando JA,Kanik KS, Gourley MF, Klippel JH, Wilder RL: In vivo geneexpression of type 1 and type 2 cytokines in synovial tissuesfrom patients in early stages of rheumatoid, ... progression of structural damage of the jointbone structure as measured by X-ray analysis.The RA joint synovial fluid and synovium contain a variety of hematopoeitic cells that are in direct proximity ... independently of theRANK/RANKL signaling pathway, via TNF and IL-1αsignaling [46]. Stimulatory, costimulatory, and/or inhibitorysignals may be provided by adjacent T cells present in theinflammatory...
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Báo cáo y học: " Transcriptional regulation of metastatic [Id]entity by KLF17" pdf
... Loss of expression of KLF17 by transcriptional suppression or inactivation by post-translational modification (possibly by phosphorylation or dephosphorylation) leads to transcription of ID1 ... amino-terminal region of KLF17. Given that the activity of some Sp1/KLF family members is known to be regulated by PKC isoforms [8,24-26], it is plausible that the ability of KLF17 to suppress ... factors might play a role in the regulation of invasion and metastasis in different cancer types.Figure 1 Regulation of ID1 expression by KLF17. ID1 transcription is suppressed by KLF17 binding...
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Báo cáo y học: "Differential regulation of diacylglycerol kinase isoform in human failing hearts" pps
... details1Department of Cardiology, Pulmonology, and Nephrology, YamagataUniversity School of Medicine, Yamagata, Japan.2Department of Cardiovascular, Thoracic, and Pediatric Surgery, Yamagata University School of ... Ohta J,Tada H, Minatoya Y, Sakuma M, Watanabe J, Goto K, Shirato K, Kagaya Y: Differential regulation of diacylglycerol kinase isozymes in cardiachypertrophy. Biochem Biophys Res Commun 2005, ... tshishid@med.id.yamagata-u.ac.jp1Department of Cardiology, Pulmonology, and Nephrology, YamagataUniversity School of Medicine, Yamagata, JapanFull list of author information is available at the end of...
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