... may be
differently regulated by inflammatory cytokines, suggesting a dynamic interplay that might have a
potential role in airway inflammation.
Background
Allergic asthma is characterised by ... airway hyperreactivity in animal studies [12-14],
they may have distinct roles in allergen-dependent airway
obstruction [24]. Hence, NGF may play a role in the early
airway response (EAR) in...
... file 2Results of confirmatory RT-PCR analyses verifying differential expression of selected transcriptsResults of confirmatory RT-PCR analyses verifying differential expression of selected transcripts.Click ... other indications of immune activation
emerged in the set of over-expressed genes, including pro-
inflammatory cytokines, chemokines, granzymes, protein-
ases, an...
... Eyk JE: cGMP-
mediated phosphorylation of heat shock protein 20 may cause smooth
muscle relaxation without myosin light chain dephosphorylation in
swine carotid artery. Journal of Physiology-London ... changes in
cell stiffness as measured by magnetic twisting cytometry. Function
efficacy of small molecules on stiffness of ASM at the level of a single
living cell. Figure S2:...
... n = 4. C Immunofluorescence study of CFTR in TSMC and D in the absence
of primary antibody. α -smooth muscle actin is stained in red, CFTR in green and nucleus (TOPRO-3 staining) in blue. Scale ... to airway smooth
muscle in CF. They shown increased smooth muscle con-
tent of the airway in subjects with CF compared to healthy
controls. This increase is due to s...
... access [14]. In contrast to all
Fe-hydrogenases including HydA of S. obliquus,the
enzyme of C. reinhardtii has an interesting additional
protein domain. A small insertion of 45 amino acids
between ... synthesis of s ome
enzymes involved in glycolysis or sugar-phosphate
metabolism [54].
HydA belongs to a new class of Fe-hydrogenases
HydA of C. reinhardtii, the first isolated gen...
... Alternatively, hTR and hTERT
may play a minimal catalytic activity in telomerase, while
the assembly of other telomerase subunits may amplify the
enzyme function. In this scenario, deletion of mTEP1 in
embryonic ... of dyskerin, although
showing comparable inhibition of telomerase function in
cells, exhibited a weaker inhibition of telomerase activity
in the in vitro ass...
... identify the
DGK isoforms in the right atrial myocardium in patients
undergoing cardiac surgery with cardiopulmonary
bypass and (2) to examine changes in expressions of
DGK isoforms in cases of failing ... protein kinase C, in the development of heart failure. DAG kinase (DGK)
acts as an endogenous regulator of GPCR signaling pathway by catalyzing and regulating DAG. Express...
... this
may be the case for the GM-CSF promoter in alveolar
macrophages from smokers [46]. Also another interest-
ing study investigating the effect of pro-inflammatory
cytokines in intestinal alkaline ... mode of action of butyrate in
IBD, where for example reports show that butyrate inhi-
bits NF-B activation and increases IBb levels in vitro
in intestinal epithelial cell lin...
... interest-
ing study investigating the effect of pro-inflammatory
cytokines in intestinal alkaline phosphatase (IAP) gene
expression comes to further support the possible role of
histone acetylation ... is involved in
pro-inflammatory cytokine gene transcription, is
increased in the intestinal mucosa o f CD patients [31].
Modulation of histone acetylation is involved in tran-
s...
... Models including the exon 6
indel were clearly inferior and are not shown, given the
lack of any previous evidence of the involvement of the
exon 6 indel in IRF5 cis -regulation. Each of the remain-
ing ... available in
the asthma collection of LCLs.
Table 1 Expression profiling studies in lymphoblastoid cell lines whose IRF5 data have been analysed
a
Study Number of
LCLs...