... plexity of the
in ammatory process: the shedding of membrane
IL-18Rα as a marker of enhanced proteolytic activity; the
activation and release of IL-18 by the in ammasome as a
marker of innate ... remains to be determined whether they can
be used as biomarkers in a clinical setting. IL-18 is a
member of the IL-1 cytokine superfamily and plays a key...
... biological therapy in RA, this
theory led to the concept of a dual-therapeutic strategy,
including anti-inflammatory biological therapy, on one hand,
and antineoplastic type drug strategies, including ... concepts and how this has far-reaching implications.
How magnetic resonance imaging changed
the way we view rheumatoid arthritis
Joint failure is the final common pathway of...
... 1667.
doi:10.1186/cc8977
Cite this article as: Abraham E: Inhaled activated protein C: a new therapy
for the prevention of ventilator-induced lung injury? Critical Care 2010,
14:144.
Abraham Critical Care 2010, 14:144 ... diminishing
the enhanced apoptosis of epithelial and other cell
populations which accompanies acute lung injury.
In the present experiments, treatment wit...
...
We are grateful to Tomohisa Kato, Akira Nasu, Takashi Kasahara, Kazuo Hayakawa,
Kyosuke Kobayashi, Michiko Ueda, Sakura Tamaki, and Yukiko Kobayashi for their
assistance. This work was partially ...
Takayuki Maruyama, Toshiya Kanaji, Shinsei Fujimura, Hikaru Sugihara, and Akio
Nishiura
are employees of Ono Pharmaceutical Co. Ltd. All other authors have no
conflicts of interest....
... history of polycythemia in her mother,
maternal grandmother and her younger sister.
Physical examination was unremarkable. Laboratory
parameters were remarkable for elevated hemoglobin
(17.2 ... change the affinity of Hb for oxygen. The
majority of mutations affecting oxygen affinity result
in high affinity Hb variants which result in leftward
shift of the dissociati...
... migration selectively [20]. In
that study a highly specific neutralizing antibody against
IL-8 was administered in several types of acute
inflammatory disease, including lipopolysaccharide/IL-1
induced ... (pro)inflammatory mediators such
as cytokines and matrix metalloproteinases [3]. Increased
expression of inflammatory chemokines has been found in
many inflammatory disorders, i...
... Corticosteroids can regulate the synthesis
and function of catecholamines and their receptors, which in
turn control vascular tone and organ perfusion [4].
Proinflammatory cytokines released in sepsis alter ... in the management
of patients with septic shock?
Frank V Ritacca*, Carmine Simone
†‡
, Randy Wax
§¶
, Katherine G Craig** and Keith R Walley
††
*Resident, Department of...
... requiring intubation and mechanical
ventilation. The patient is admitted to the intensive care unit
and, in the course of investigation, he has an abdominal
computed tomography scan that shows an inflamed ... difference in the rate of infection of pancreatic necrosis
[4].
Pooling of the data from these 183 patients by Bosscha and
colleagues in a meta-analysis resulte...
... effects and calcium
channel blockade. Although the availability of free fatty acids
is maintained, myocardial extraction is decreased, making the
heart dependent on carbohydrates as an energy supply. ... within 30 days.
Adverse effects
Hypoglycaemia and hypokalaemia are the main adverse
effects that can be expected during insulin infusion.
Hypoglycaemia
Some patients with hyperglycaem...
... this
regulatory function has transformed our thinking on the role of RNA in many facets of biology,
illustrating the complexity and the dynamic interplay of cellular regulation. As plants and
invertebrates ... some of the mam-
malian virus-encoded proteins, such as influenza viral
protein NS1 and vaccinia viral protein E3L, have a nega-
tive regulatory role on RNA silencin...