... Institutes of Health and the American Physio-logical Society for the care and use of laboratory animals.Animal modelThe ovine model of ALI and sepsis induced by smoke inhalation and instillation of ... with an early and transient increase in eNOS and an early and profound increase in iNOS expression, while expression of nNOS remained unchanged. Both 3-NT, a marker of protein nitration, and PAR, ... deterioration of pul-monary function, which was associated with early over-expression of eNOS and iNOS, enhanced NOS activity, and increased expression of markers of nitrosative stress and DNA damage...