Báo cáo y học: "Efficacy and safety of tiotropium in COPD patients in primary care – the SPiRiva Usual CarE (SPRUCE) study" ppsx

... purposes)Respiratory ResearchOpen AccessResearchEfficacy and safety of tiotropium in COPD patients in primary care – the SPiRiva Usual CarE (SPRUCE) studyDaryl Freeman*1, Angela Lee2 and David ... under-diagnosed and the role of primary care is critical to early and correct diagnosis,since a large proportion of smokers with early symptoms of COPD are first seen by their primary care physician ... purposes)DiscussionThis study, which is the first study with tiotropium con-ducted in primary care, was conducted to assess the effi-cacy and safety of tiotropium when introduced to usual primary care management...

Báo cáo y học: "Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review" pdf

... (dehydro-genation, hydroxylation, and N-dealkylation), mainly bycytochrome P450 2D6 (CYP2D6) and cytochrome P4503A4 (CYP3A4) [60]. The parenteral drug is excreted only in traces. There is only ... by 142(76%) of the 186 patients in the placebo group and 154(87%) of the 178 patients in the aripiprazole group. The most frequent adverse events (≥5% incidence in the arip-iprazole group and ... (41%) and 13out of the 27 in the placebo group (48.1%)). The only dif-ference concerned manic relapses (nine in the placebo and six in the aripiprazole group). Again the YMRS scoresignificantly...

Báo cáo y học: " Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold" doc

... spray (black squares) and Placebo (black triangles) treatment groups. The y axis shows the day of recording. The y axis shows the study day; i indicates the point of inclusion into the study.Eccles ... efficacy analysis of symptoms. In total,14 Iota-Carrageenan patients and 18 placebo patients were eligible for analysis of symptoms. The predefined primary efficacy parameter for the trialwas the ... determination of the therapeutic effect of the Iota-Carrageenan nasalspray. The study population consisted mainly of studentswith a mean age of 19.6 ( SD 1.2) years, and the compli-ance was very...

Báo cáo y học: " Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease" potx

... III st udies,ACCLAIM /COPD (AClidinium CLinical trial Assessingefficacy and safety In Moderate to severe COPD patients) I and II, to assess the long-term efficacy and safety of * Correspondence: ... of dry mouth, urinary retention and arrhyth-mias [24, 25]. In the ACCL AIM /COPD studies, the inci-dence of anticholinergic AEs was similar between the two groups. Although safety analyses of ... design of the study and the interpretation of the study data. RL supervised the statisticalanalysis. All authors contributed to the development of the manuscript, and read and approved the final...

Báo cáo y học: "Efficacy and safety of non-invasive ventilation in the treatment of acute cardiogenic pulmonary edema – a systematic review and meta-analysis" docx

... for clinicians to understand. The aim of our study was to systematically review the evidence in order to answer key clinical questions about the efficacy and safety of CPAP and NPPV in the treatment ... related to the extreme findings of 55% risk reduction for both ETI and mor-tality in the study by Takeda and colleagues [12].Only three studies included data on myocardial infarction and the random ... 0.430).To explore the hypothesis proposed by some clinicians on the advantage of NPPV over CPAP in hypercapnic patients [19],we analyzed the impact of patients& apos; baseline hypercapnia in the comparison...

Báo cáo y học: "Effectiveness and safety of adalimumab in patients with ankylosing spondylitis or psoriatic arthritis and history of anti-tumor necrosis factor therapy" pdf

... 12:R117http://arthritis-research.com/content/12/3/R117Page 11 of 11Recombinant Infliximab Therapy Study Group: Efficacy and safety of infliximab in patients with ankylosing spondylitis: results of a randomized, placebo-controlled ... studies, we investigated the effectiveness and safety of adalimumab in treating patients with active ASor PsA who had a history of therapy with IFX or ETN orboth: Review of Safety and Effectiveness ... points for patients with ahistory of anti-TNF therapy (Figure 1). For patients withpsoriatic nail dystrophy at baseline, the median change in NAPSI was similar in patients without and in patients with...

Báo cáo khoa học: "Efficacy and safety of a low-flow veno-venous carbon dioxide removal device: results of an experimental study in adult sheep" pps

... over-distension and cyclic inflation and deflation of alveoli can damage the alveolar–capillary barrier and initiate oramplify a local and systemic inflammation, so the concept of ventilator-induced lung injury ... Nochanges in ventilatory setting were made during the treatment.A bolus of 2,000 UI of heparin was administered intravenously,followed by an infusion titrated to maintain ACT (activated clot-ting ... study was designed to evaluate the efficacy and safety of a veno-venous CO2 removal device in an animal model. Byusing an EBF of up to 5% of cardiac output, we succeeded in reducing PaCO2 by...

Báo cáo y học: "Utility and safety of draining pleural effusions in mechanically ventilated patients: a systematic review and meta-analysis" pps

... not likely explain the immediate relief of dyspneareported by many patients. Alternatively, draining pleural effusions may reduce the work of breathing by impr oving the mechanics of the diaphragm. ... (asdefined in each study), and the remaining 3 % had inde-terminate biochemical findings.Methodological qualityThere were no randomized or non-randomized con-trolled trials of effusion drainage. ... the level of training of the operator, and the type of drainage proce-dure performed; and outcomes. Only outcomes reported in mechanically ventilated patients were abstracted. Forphysiologic...

Báo cáo y học: "Expression and function of junctional adhesion molecule-C in human and experimental arthritis" pot

... tissuesWe investigated JAM-C expression in human OA and RA syn-ovial samples by IHC using polyclonal antibodies againsthuman JAM-C. Interestingly, expression of JAM-C was mainlyfound in the lining ... similar to that found in human arthritic tissues. Expression of the protein was mainlyfound in the lining layer and was associated with vessels in the sublining layer. RT-PCR analysis showed JAM-C ... bysynovial fibroblasts in the lining layer and associated withvessels in the sublining layer in human and mouse arthriticsynovial tissue. In human tissue, JAM-C expression wasincreased in...

Báo cáo y học: " Signaling and regulation of G protein-coupled receptors in airway smooth muscle" ppsx

... high-affinity binding site for a G-protein in its GDP-bound inactive state. The receptor spe-cifically interacts with the C-terminus of the α subunit of the G-protein heterotrimer. G-protein binding ... JM and Hoffman BB Isoform-specific sensitization of adenylyl cyclase activity by prior activation of inhibitory re-ceptors: role of beta gamma subunits in transducing en-hanced activity of the ... 282:L1305-L1313127. Pyne S and Pyne NJ Bradykinin-stimulated phosphatidylcholinehydrolysis in airway smooth muscle: the role of Ca2+ and protein kinase C Biochem J 1995, 311:637-642128. Taussig R and Gilman...

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