... motifs, one at the N- and the otherat the C- terminus [20]. p21/waf1 (mut) is mutated at the N-terminus and is therefore still able to bind to cyclinsthrough the C-terminus, making this protein ... within the Nterminus and the other at the C terminus [20]. p21/waf1interacts with both cyclins and cdks, in contrast to the INKfamily CDKI members, which only bind to cdks [20].Interestingly, ... [28,30]. Tax also has the abil-ity to increase cdk4 associated kinase activity in HTLV-1infected cells by binding to p16/INK4A, resulting in the inability of p16/INK4A to effectively inhibit cyclin...