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Báo cáo y học: "Gene expression profiling in circulating endothelial cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by iloprost infusion" potx

Báo cáo y học:

Báo cáo y học: "Gene expression profiling in circulating endothelial cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by iloprost infusion" potx

... expression profiling in circulating endothelial cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by iloprost infusion. Arthritis Research ... cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by iloprost infusionElisa Tinazzi1†, Marzia Dolcino2†, Antonio Puccetti2,3*, Antonella ... to controls. Indeed, patients displayed an altered expression of genes involved in the control of apoptosis and angiogenesis. Iloprost infusion had a profound impact on endothelial cells gene expression...
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Báo cáo y học: "Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation" pps

... experimental processes and in the finalization of themanuscript. EGB controlled Affymetrix hybridization and scanning experiments, managed preliminary data analysis and finalized the manuscript. TTG designed ... interpretation of data in gene expression stud-ies. Animal models of RA can facilitate the interpretation of genome-wide gene expression by providing genetic and clinical homogeneity, and an opportunity ... from the National Cancer Institute and maintained under germ-free conditions.Stimulation of lymphocytes in vitro, and adoptive transfer of arthritisTo ensure uniformity and reproducibility...
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Báo cáo y học: "Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis" doc

... and immunohistochemistry experiments and by linking our data topotential mechanisms of resistance to TNF blockade in RA.Our findings about the changes induced by adalimumab in synovial tissue between T0 and ... any rel-evant pathway. It should be stressed in that perspective that RA is not a systemic disease. The inflammatory mechanismstargeted by TNF-blocking agents are located in the synovium, and ... discriminate RA from other joint dis-orders based on the analysis of synovial molecular profilesonly, thereby demonstrating the power of this approach [28]. In this perspective, Lindberg and...
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Báo cáo y học: "Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts" docx

... genes included potential key candidates in theregulation by TGFβ of lung tissue fibrosis and includedangiotensin II receptor type 1 (AGTR1), SMURF2, a geneinvolved in terminating TGFβ signalling, ... the accessory receptorbetaglycan, a membrane anchored proteoglycan whichincreases the affinity between TGFβ and type I and IIreceptors. Interestingly, TGFβ upregulated activin A type Ireceptor, ... in the microarray work, performed immunohistochemistrystaining, and drafted the manuscript. DJA participated in the design and coordination of the study and in the prep-aration of the manuscript,...
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Báo cáo y học: " Gene expression profiling of Hfe-/- liver and duodenum in mouse strains with differing susceptibilities to iron loading: identification of transcriptional regulatory targets of Hfe and potential hemochromatosis modifiers" pdf

... They alsoNumber of genes regulated by Hfe disruption by mouse strain and organ studiedFigure 1Number of genes regulated by Hfe disruption by mouse strain and organ studied. Genes regulated by ... has not yet been observed and is inter-esting within the context of recent reports indicating that Zip4 is a minor intestinal iron importer [26] and that Zip14mediates non-transferrin-bound ... mice.Interestingly, the cholesterol metabolism category is alsoenriched among genes downregulated by Hfe deficiency in D2mice, and this mainly affects genes that are involved in thecatabolism of...
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Báo cáo y học: "Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis" docx

... inflam-matory disease of unknown aetiology that is characterized by infiltration of monocytes, T cells and polymorphonuclear cells into the synovial joints. The pathogenesis of this dis-ease is still ... this model, asynovitis with maximal swelling at 24 hours is induced by local injection of SCW antigen directly into an ankle joint.The initial response is reactivated by systemic (intravenous)challenge ... Hence, analysis of the damaged tissue, rather than analysis of an isolated celltype, increases the probability that differential gene expres-sion will be examined in those cells that are important...
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Báo cáo y học: "Degradome expression profiling in human articular cartilage" potx

... helped in collecting and processing tissue samples, and advised running and inter-preting low-density arrays. CJP and XSP designed the low-density arrays. CD and AC took patient consent and coordi-nated ... demonstrate that assigning relativeimportance to any gene in distinguishing OA from NOF is nottrivial. Unsupervised cluster analysis shows that the samplesare separated into OA and NOF based ... osteoarthritis (OA) versus fracture to the neck of femur (NOF). P value from the Mann-Whitney U test. ADAM, a disintegrin and metalloproteinase domain; ADAMTS, a disintegrin and metalloproteinase domain...
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Báo cáo y học: "Gene expression profiles in BCL11B-siRNA treated malignant T cells" ppt

... BCL2L1, and CREBBP genes in primary T-ALLsamples blocks apoptosis in malignant T cells [15]. Thisstudy suggests that inhibition of BCL11B may trigger apoptosis in leukemic T cells by downregulating ... downre-gulation of CREBBP was identified in the microarrayanalysis, but not confirmed by real-time PCR analysis.The reason may be due to a systemic error on themicroarr ay analysis. Interestingly, unlike ... T cells After obtaining interesting data from Molt-4 cells, weanalyzed the effect of the BCL11B-siRNA in primary T-ALL cells. We examined the expression levels of TNFSF10, BCL2L1, SPP1, and...
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báo cáo khoa học: " Gene expression profiling in susceptible interaction of grapevine with its fungal pathogen Eutypa lata: Extending MapMan ontology for grapevine" pdf

... setup and analysis of Eutypa lata exper-iment. SP and CM were involved in validation grapevineMapMan for Affymterix microarrays. KG was involved in organization of the work and writing of the manuscript.Additional ... UV-scavengers and are involved in disease resistance [13]. In red grape, flavanols and anthocyanins are the most abundant flavonoid classes,the latter accumulating mostly in berry skin and theformer in ... Arabidopsis plants over-expressingPGIPs exhibit enhanced resistance to Botrytis cinerea [43].Induction of phenylpropanoid pathway in eutypiosisSecondary metabolism was also strongly induced afterinfection...
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Báo cáo y học: " Gene expression variation in Down''''s syndrome mice allows prioritization of candidate genes" potx

... genes in the eight trisomic and control mice.Variation of gene expression in the brains of Ts65Dn and control miceAnalysis of individual samples allows recovery of importantinformation that cannot ... directly, and to the best of our knowledge this is the first report dealing with this impor-tant issue, an appreciation of which is essential to our under-standing of DS and aneuploidies in general. ... of gene expression and its contribution to pathogenesis in DS.As shown here, stratification of populations by expression profiling provides an essential dimension in the molecularanalysis of aneuploidy...
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