... distribution, and reproduction in
any medium, provided the original work is properly cited.
Research article
Remission in psoriatic arthritis: is it possible and
how can it be predicted?
Tajvur P Saber
1,2
, ... 10.1186/ar3021
Cite this article as: Saber et al., Remission in psoriatic arthritis: is it possible
and how can it be predicted? Arth...
... low.
Introduction
Rheumatoid arthritis (RA) is a chronic, autoimmune, inflamma-
tory disorder of unknown aetiology that is characterized by
symmetric synovitis and the propensity to cause joint ... – including monitoring, comedication and
even the increasingly employed paradigm to change therapy if
a state of low disease activity is not reached within few months
[16,17] – re-prescri...
... inset b) is important
for HA binding in Jurkat cells. Cys-266 and Cys-275 can
be used for palmitoylation. The cytoplasmic tail includes
the binding sites for ezrin radixin moesin and for ankyrin as
well ... RA-like synovial fibroblasts, which invade
Matrigel, as monitored by transwell assay in vitro, are
enriched in v3- and v6-containing CD44 isoforms. This
invasion was sign...
... radicals inhibit the synthesis of
matrix components including proteoglycans by chondro-
cytes. In particular, NO and O
2
seem to inhibit type II
collagen and proteoglycan synthesis and the sulfation ... fragment hyaluronan and
chondroitin sulfate [39,40] and damage the hyaluronan-
binding region of the proteoglycan core protein, thereby
interfering with proteoglycan–hyaluronan int...
... arthritis as a distinct clinical entity remains a topic of debate; some authors
propose that it is simply the co-occurrence of psoriasis and inflammatory arthritis. However, a distinct
entity is ... controversy over the distinctiveness of PsA is important
to bear in mind when investigating potential susceptibility
factors. A distinct entity is likely to have a distinct aetiology...
... obtained by review of follow-up visits and by stand-
ardized telephone interviews. Statistical analysis was done by
χ
2
test and linear multiple discriminant analysis for categorial
data and by t-tests ... distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Pseudoporphyria (PP) is characterized by skin fragility, blistering
and...
... clinical severity in patients already
affected by active RA. In particular, gonadal and adrenal androgens
(that is, testosterone and DHEAS) are significantly decreased in
inflamed synovial tissue/fluids ... remission in early RA.
Introduction
The study by Karlson and colleagues in Arthritis Research
and Therapy [1] confirms that neither hormone receptor
genes nor plasma and...
...
function and vasculogenesis in RA and low EPC numbers
may be associated with RA activity and increased
cardiovascular risk, late-outgrowth EPCs of solely
heman gioblastic origin may be involved in ... this EPC subset may be preferentially involved
in the active stage of the disease, it is likely that
hemangioblastic EPC-dependent vasculogenesis is more
prominent...
...
monitoring and confirming resistance to lamivudine therapy. Indeed, resistance to antivirals is still generally defined clinically by a
rise in serum HBV DNA levels during antiviral therapy. ... it is increasingly apparent that clinically relevant prediction and monitoring of viral resistance may not only require the
use of existing tools such as drug resistance and viral loa...
... matrix staining within the vicinity of the
injected cells was also observed 1 week following injection,
and the intensity of the matrix staining increased with time in
culture (Figures 4 and 5b).
Weak ... paraffin
embedding, cell viability was assessed using in situ
hybridisation for polyA-mRNA and using immunohistochemistry
for caspase 3. Immunohistochemistry/fluorescence for
aggre...