Báo cáo y học: " Mitogen-activated protein kinases and NFκB are involved in SP-A-enhanced responses of macrophages to " pdf
Báo cáo y học: " Mitogen-activated protein kinases and NFκB are involved in SP-A-enhanced responses of macrophages to " pdf
... SD.ResultsHerbimycin A inhibits nitric oxide production induced by BCG and SP-A-BCG complexesActivation of intracellular protein tyrosine kinases is acommon pathway involved in signalling induced by avariety ... purposes)inflammatory mediators by rat macrophages in response to BCG through increased activation of intra-macrophagesignalling pathways involving MAP kinases and NFκB. Wehave examined the role of ... kinase family [10-12].MAP kinases are a family of serine/threonine kinases that are activated by phosphorylation of conserved tyrosineresidues [13]. Multiple members of this family includingthe...
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Báo cáo y học: "κ Increased AP-1 and NF-κB activation and recruitment with the β combination of the proinflammatory cytokines IL-1β, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocyte" ppt
... combinations of these cytokines.Immunofluorescence stainingImmunofluorescence staining was performed on control and stimulated rheumatoid synoviocytes (i.e. before and 30 min after cytokine ... tumor necrosisfactor alpha (TNF-α) and IL-1 inhibitors strongly supportthe importance of cytokines in RA. These cytokines are key activators of the TFs AP-1, Egr-1 and NF-κB. Bindingsites for ... and maycontribute to the mode of action of cytokine inhibitors.Keywords: proinflammatory cytokines, rheumatoid arthritis, synoviocytes, transcription factorsOpen Access and JunD nuclear translocation...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf
... neutrophil infiltration into the lungs and to increased pulmonary proinflammatory cytokine expression [7].However, the initial events induced by hyperoxia, therebyleading to acute inflammatory lung injury, ... leads to increasing intracellular stores of GSSG, a potent inhibitor of NF-κB transcription factor DNA binding. The pathway leading to the formation of GSH by the action of γ-glutamylcysteine synthetase ... resuscitation In murine models, for example, mRNA levels of proinflamma-tory and immunoregulatory cytokines, including IL-1α, IL-1β,transforming growth factor beta 1 and TNF-α, are increased in intraparenchymal...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx
... lung injury, ischemia-reperfusion and transplantation, compromised host defense and inflammatory stimuli, and hypoxemia and the crucial role of hypoxia-inducible factor in mediating lunginjury. ... 28:920-925.41. Haddad JJ: Oxygen-sensitive pro-inflammatory cytokines,apoptosis signaling and redox-responsive transcriptionfactors in development and pathophysiology. Cytokines CellMol Ther 2001, ... Normoxicinduction of the hypoxia-inducible factor 1ααby insulin and interleukin-1ββinvolves the phosphatidylinositol 3-kinasepathway. FEBS Lett 2002, 512:157-162.50. Haddad JJ, Land SC:...
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Báo cáo y học: " Interactions Between Estrogen- and Ah-Receptor Signalling Pathways in Primary Culture of Salmon Hepatocytes Exposed to Nonylphenol and 3,3'''',4,4''''-Tetrachlorobiphenyl (Congener 77)" ppsx
... expression patterns of ERα (A), ERβ (B), Vtg (C) and Zr -protein (D) mRNA in primary cul-ture of salmon hepatocytes exposed to 5 μM NP and 1 μM PCB-77, both singly and in combination. Hepatocytes were ... domains, the N-terminal bHLH and the PASdomain [2,3]. Cytochrome (CYP) P450 enzymes(CYP1A1, 1A2, 1B1) are involved in the metabolism of awide variety of structurally different chemicals thatinclude ... protein (Vtg) and eggshell protein (Zr -protein) precursor, respectively, their secretion and transport in blood to the ovary and their uptake into maturing oocytes[4,5]. The ERs (ERα and ERβ) are...
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Báo cáo y học: " Possible Cis-acting signal that could be involved in the localization of different mRNAs in neuronal axons" potx
... likely that β-actin and tropomyosin are not exclusive to the axon and could be also found in dendrites.Cofilin is a cytoskeleton modulating protein; it is alsoknown as actin depolymerizing factor ... S, Shenoy SM, Hartley A, StantonPK, Singer R, Bassell GJ: Activity-Dependent Trafficking and Dynamic Localization of Zipcode Binding Protein 1 and β-Actin mRNA in Dendrites and Spines of HippocampalNeurons. ... again they are probably not exclusive to the axon. They could interactwith other proteins in different parts of the cell.Synuclein is a soluble unfolded protein that can aggregateinto insoluble...
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Báo cáo y học: " Perceived protein needs and measured protein intake in collegiate male athletes: an observational study" potx
... Protein Intake. The RDI, maximum beneficial level of protein intake, and the mean actual protein intake as determinedby 3-day food record analysis in grams of protein per kg of bodyweight per day.3040506070% of EnergyIntakeRecommendedIntakeActualIntakep=0.006p020p=0.0510203040506070Carbohydrate ... perception of protein needs by as king the subjects to list, in g/kg/d, g/lb/d and % daily calories, “how much protein do you think you need to get the biggest benefitfrom your training program and to ... result in excessive use of protein supplements and excessivedietary protein intakes. The purpose of the presentstudywastoinvestigatecollegiateathletes’ perceived protein needs and actual protein intake...
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báo cáo hóa học: " Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes" pdf
... transcriptional up-regulation of inflammatory cytokines and chemokines during hypoxia;whereas NFκB is mainly involved in transcriptional regu-lation of these genes during the phase of reoxygenation[8,40]. ... and infiltration of inflammatory cells in focal brain ischemia of hypertensive rats [38]. Astrocytes are main cytokine/chemokine-producing cells in the brain [34,37], and astrocyte-produced MCP-1 ... transmigration of monocytes and macrophages across the BBB to the sites of axonal injury in the brain [33,37]. Both in vitro and in vivofindings suggest that hypoxia/ischemia-induced infiltra-tion of monocytes...
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Báo cáo y học: "Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration" docx
... proposed to mediate SIPS in murine fibrob-lasts and human articular chondrocytes in response to oxidative stress and the inflammatory cytokine interleukin-1β(IL-1β) (both of which are known to be increased ... Christine Lyn Le Maitre2 and Judith Alison Hoyland11Tissue Injury and Repair Group, Research School of Clinical and Laboratory Sciences, Faculty of Medical and Human Sciences, Stopford Building, ... themajority of the laboratory work and analysis, and drafted themanuscript. CLM helped to secure funding, participated in thedesign of the study and the interpretation of data, and assisted in the...
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Báo cáo y học: "Pu-Erh tea and GABA attenuates oxidative stress in kainic acid-induced status epilepticu" docx
... expression of heat shock protein HSP-70 mRNA,brain-derived neurotrophic factor mRNA, and cyclooxygenase-2 mRNA in rat brain following seizures induced by systemic administration of kainic acid. Brain ... showingsuppression of ROS and Ca2+release by PETL are con-sistent with the proposed role of GABA and PETLextract in neuronal protection.Cytokines and chemokines play key roles in theinflammatory ... 10 of 10DiscussionThe main result of the present study is the findingPETL and GABA protected animals from KA-inducedbrain injury. MDA and apoptosis w ere significantlyreduced in the GABA and...
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