... Control and Prevention: Hepatotoxicity of
rifampin and pyrazinamide in the treatment of latent tuberculosis
infection in HIV-infected persons: is it different than in HIV-uninfected
persons? Clin Infect ... of targeted t ubercu-
lin skin testing and IGRAs to identify latently infected
individuals and their treatment for LTBI has greatly
helped in lowering the...
... overlapping peptides derived from several
of these proteins.
‘Myelin proteome’ arrays
Our ‘myelin proteome’ arrays contain 500 proteins and
peptides derived from the myelin sheath, the target of the
autoimmune ... Autoantibody profiling may serve purposes including classification
of individual patients and subsets of patients based on their ‘autoantibody fingerprint’, examin...
... that
using the current DSM-IV criteria that stipulate six of
nine symptoms of either inattention or hyperactivity-
impulsivity, a lower threshold of four of nine of these
symptoms in either domain ... remission of
ADHD symptoms in adult life. There is a great deal of
interest in the mechanisms by which the disorder per-
sists in some individuals and remits in o...
... in
rats and pigs.
Kinase inhibitors
In a session on the role of protein kinases in airway inflam-
matory diseases several speakers discussed target identi-
fication, validation and the profiling of ... NH
2
-terminal kinase
1, 2 and 3 but is not orally available and is being tested as
a proof of concept molecule. It showed good anti-inflam-
matory activity in a range...
... tissues acting to increase the excitability of the
nociceptive pathway and has the effect of making everyday
Review
Arthritis and pain
Current approaches in the treatment of arthritic pain
Bruce ... be
confined to the periphery. The finding of increased areas of
punctate hyperalgesia in patients with RA after topical
application of capsaicin is in accord...
... (ST) and
synovial fluid (SF). The inflammatory infiltrate consists pre-
dominantly of B lymphocytes, T lymphocytes and macro-
phages in the ST, whereas neutrophils are mainly found in
the SF. The ... on the study
or coordinated the collection of samples in Birmingham,
and contributed to the writing of the manuscript. JM con-
ceived the study, and particip...
... State
Examination (PSE) to 3293 participants at home [20]. The
PSE assesses the frequency and severity of psychiatric
symptoms in the preceding month and can be coded as an
index of d efinition ... funding for this study.
Author details
1
Clinical Senior Lecturer in Epidemiological and Occupational Psychiatry
King’s College London, Institute of Psychiatry Department of...
... hyroxymethyl cytosine or that they glycosylate their
DNA. In addition all of the r genes in T4 that are
known to be in volve d in superinfection and lysis inhibi-
tion [45] are missing in cyanophage ... P-SSM4 and S-RMS4. speD
encodes S-adenosylmethionine decarboxylase a key
enzyme in the synthesis of the polyamines spermidine
and spermine. With polyamines implicat...
... nature of the biosyn-
thetic enzyme complex and the subsequent transport of
the phytochemical product to the site of accumulation.
Anthocyanins are synthesized in the cytoplasm, likely by
a multienzyme ... participated in the
investigation on AVI morphology. K.D. contributed to the
initiation of the project and was involved in design and
supervision of t...
... (mainly secondary to inactive tuberculosis) ,
cancer, active tuberculosis and mycetoma were the lead-
ing causes. Such a distribution of the causes of haemopty-
sis underlines the following points: ... discharge, when
the procedure was completed.
Using a strategy including a routine assessment of the
amount of bleeding with a standardized scale, and pro-
moting BAE ov...