Báo cáo y học: " Inhibitor of IκB kinase activity, BAY 11-7082, interferes with interferon regulatory factor 7 nuclear translocation and type I interferon production by plasmacytoid dendritic cells" ppsx
Báo cáo y học: " Inhibitor of IκB kinase activity, BAY 11-7082, interferes with interferon regulatory factor 7 nuclear translocation and type I interferon production by plasmacytoid dendritic cells" ppsx
... provided the original work is properly cited.Research article Inhibitor of I B kinase activity, BAY 11 -70 82, interferes with interferon regulatory factor 7 nuclear translocation and type I interferon ... inhi-bition of type I IFN production by BAY1 1 is due to itsinhibitory function on the nuclear translocation of IRF7.Unlike type I IFN production, inflammatory cytokine and chemokine production have ... 203: 179 5-1803.doi: 10.1186/ar3014Cite this article as: Miyamoto et al., Inhibitor of I? B kinase activity, BAY 11- 70 82, interferes with interferon regulatory factor 7 nuclear translocation and...
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Tài liệu Báo cáo Y học: Proteolysis of bovine b-lactoglobulin during thermal treatment in subdenaturing conditions highlights some structural features of the temperature-modified protein and yields fragments with low immunoreactivity pptx
... University of Milan, Italy;2Biocentrum, Technical University of Denmark,Lyngby, Denmark;3Istituto di Scienze dell’Alimentazione, CNR, Avellino, ItalyBovine b-lactoglobulin was hydrolyzed with ... thatapparently are b etter explained b y assuming an inhibitoryeffect of the peptides produced by hydrolysis of BLG at hightemperature.Table 1 . Thermal stability of trypsin and chymotrypsin. Proteins ... activity a nd with the reversibility of structural modifications of BLG. Limitedproteolysis studies on BLG are s ignificant not only t ounderstanding its unfolding mechanism, but may havepractical...
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Báo cáo y học: "κ Regulation of NFκB signalling during inflammation: the role of hydroxylases" potx
... activity. Factor- inhibiting hypoxia inducible factor inhibition by hypoxia or pharmacological inhibition reduces I B asparaginyl hydroxylation but does not appear to affect I B degradation. ... Schofield CJ, Ratcliffe PJ: Post-translational hydroxylation of ankyrin repeats in I κκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). ... conditions of hypoxia as well as in theliver and brain of hypoxic animals. IKKβ links the hypoxicresponse and innate immunity since a deficiency in IKKβleads to ineffective induction of HIF-1α...
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Báo cáo y học: "Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase" pptx
... set out toidentify the capacity of G6PI to induce chronic arthritis in mice.Immunization with recombinant human G6PI induced achronically active arthritis in mice with a C3H genomicbackground, ... collagen type II (CII) [7, 8]. B-cell activation inresponse to G6PI appeared to occur primarily in lymph nodesdraining the joints [9], indicating that recognition of G6PI isjoint specific. The ... analysis of patients with different forms of arthritides revealed that G6PI-specific antibodies may be identified not only in severe forms of RA but also in ankylosing spondylitis and Reiter's...
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Báo cáo y học: "Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation" pps
... and inhibition by WFAFigure 5Quantification of p65 translocation upon PAF stimu-lation and inhibition by WFA. Quantification of p65 translocation into nuclei of KKLEB cells under various test ... aggregationinduced by withaferin A is mediated by annexin II. Nat ChemBiol 2006, 2:33-38.25. Jayaprakasam B, Zhang Y, Seeram NP, Nair MG: Growth inhibition of human tumor cell lines by withanolides from Withaniasomnifera ... transcription of several genes that are involved in inflammation, anti-apoptosis and anti-microbial activity, and hyper-activation of this transcription factor leads to a potent inflammatory response....
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Báo cáo y học: "Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians" pps
... increase with age; however this trend was not statistically signifi-cant . In multivariable logistic analysis, onl y m ale gender and HIV type were significantly associated with HBcAbpositivity. ... seroprevalence of HBV and HCV virus in HIV-infected subjectsin the Gambia.Methods: Plasma samples from HIV infected patients (190 individuals with clinically defined AIDS and 382individuals without AIDS) ... be in the inactive carrierphase [30]. This is the thi rd phase of chronic hep atitis Bthat is traditionall y identified by the absence of HBeAg and HBV DNA for potentially indefinite duration....
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Báo cáo y học: " Characterization of Hepatitis B virus (HBV) genotypes in patients from Rondônia, Brazil" doc
... been divided into subgenotypes with distinct virological and epidemiological properties.In addition, recombination among HBV genotypesincreases the viral variability itself [ 17] .Genotype A is ... Sastrosoewignjo RI, Imai M, Miyakawa Y, Mayumi M: Typing hepatitis B virus by homology in nucleotidesequence: comparison of surface antigen subtypes. J Gen Virol 1988,69(Pt 10):2 575 -2583.48. ... and clinical associations of genotypes. Hepatol Res 20 07, 37: S9-S19.32. Osiowy C, Gordon D, Borlang J, Giles E, Villeneuve JP: Hepatitis B virusgenotype G epidemiology and co-infection with...
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Báo cáo y học: " Seropositivity of Hepatitis B virus and Hepatitis C virus dual Infection among blood donors in Nyala Teaching Hospital" pot
... viral hepatitis in thalassemicchildren receiving multiple blood transfusions. Indian Journal of Gastroenterology 2002, 21:183-184. 7. Liaw YF: Hepatitis C virus superinfection in patients with chronic ... users in Manipur-A preliminary report.Indian Journal of Medical Microbiology 2004, 22(2):136-1 37. 2. Pallas JR, Farinas-Alvarez C, Prieto D, Delgado-Rodriguez M: Coin-fection by HIV, Hepatitis ... HBV and HCV dual infection in patientson hemodialysis. Indian Journal of Medical Microbiology 2005,23:41-43.4. Aroldi A, Lampertico P, Montagnino G, Passerini P, Villa M, CampiseMR, Lunghi...
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Báo cáo y học: " Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction" pps
... theRhoA/Rho -kinase pathway [7, 6]. Activated Rho -kinase interferes with the equilibrium of MLCK and MLCP activ-ities by phosphorylating and thereby inactivating themyosin binding subunit of MLCP. This ... neutrophils in inflam-mation. Clin Exp Allergy 2000, 30 Suppl 1:22- 27. 20. Henry PJ, Mann TS, Goldie RG: A Rho kinase inhibitor, Y- 276 32inhibits pulmonary eosinophilia, bronchoconstriction and airways ... inhibition. In addition, Rho -kinase inhibi-tion might have effects on airway inflammation itself, ashas been suggested in a murine model of acute allergic air-way inflammation. In anaesthetized...
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Báo cáo Y học: Effect of the disease-causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII pot
... sequences (Fig. 4A),is located in the vicinity of this residue (Fig. 7) .Therefore, it is likely that introduction of a bulkyresidues into this position forcibly shifts the position of Tyr 170 to ... active. Introduction of the bulky side chains of Pro and Leu in this position causes a significant con-formational change around the substrate binding site and active site, and thereby inactivates ... protein to analyze the role of Gly 37 in the catalytic subunit of human RNase H2,which is fully conserved in prokaryotic RNases HII and eukaryotic RNases H2. Because Tk-RNase HII iscatalytically...
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