Báo cáo y học: "B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgRIIb, which are modulated by anti-tumor necrosis factor therapy" potx

... Open AccessB cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgRIIb, which are modulated by anti-tumor necrosis factor therapyDiego Catalán1, ... coordination of the study. AMK participated in the conception and design of the study and critically revised the manuscript. JCAparticipated in the conception and design of the study and in the interpretation ... altera-tions in the phenotype of peripheral B cells from RA patients, involving the expression of the co-stimulatorymolecule CD86 and the inhibitory receptor FcgRIIb, the latter being associated...

Báo cáo y học: "Immune complexes from rheumatoid arthritis synovial fluid induce FcγRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-α by peripheral blood mononuclear cells" potx

... stimulation.Recent therapeutic interventions such as anti-TNF-α and inter-leukin-1 inhibition show the importance of cytokines in RA[16]. Induction of proinflammatory cytokines via cross-linking of FcγR by ... vaccination in healthyindividuals during the time interval when antibodies and anti-gen form circulating ICs [4]. RF-producing B cells are present in the inflamed joints of RA patients [22] and ... inflammation in individual patients. We are currently studying the cytokine inducing properties of pairedSF samples from different joints obtained at the same timepoint, as well as paired SF samples from...

Tài liệu Báo cáo Y học: Granule-bound starch synthase I A major enzyme involved in the biogenesis of B-crystallites in starch granules ppt

... iodine and the levels of amylopectin and amylose were determined by amyloglucosidase assays (Roche). In vitroassay of GBSSI activityThis assay is fully described in both [18] and [22]. Brie y, 50 ... rate of amylopectin synthesis. The increase in crystallinity wit-nessed during these ﬁrst 12 h is in line with the high ratesobserved for amylopectin synthesis. However between 12 and 58 h the ... further distinguished from glycogen by the presence of highly ordered parallel arrays of double helical glucans (reviewed in [5]). The origin of these arrays resides in the close packing of the...

Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx

... to the mechanism underlying proteinstability at the amino-acid level. The molecular mechanismsunderlying protein maturation, folding, and stability in bacterial cytochromes c are beginning ... together with the results from rapidly increasing X-ray crystal and NMRanalyses, have stimulated mutagenesis studies, which con-tribute to the understanding of the mechanisms underlyingprotein maturation, ... and evolution.Cytochrome c is unique among heme proteins in having aheme covalently attached to the polypeptide chain via twothioether bonds, formed from the vinyl groups of the heme and the...

Báo cáo y học: "B cells as a therapeutic target in autoimmune disease" doc

... clinical investigation and estab-lished the foundation of modern clinical immunology. The original descriptions of antinuclear antibodies by Holman and Kunkel [1] and of rheumatoid factor by ... upstream of the current treatment regimens employing cytokine blockage and that may be well suitable for a subset of patients. Identifying the mechanisms by which B cells controldisease activity will ... hypothesized that this is the main function of physiological rheumatoid- factor- produc-ing B cells, which are preferentially found in the mantlezones of lymphoid follicles [33]. Expansion of a B-cellsubset...

Báo cáo y học: "B cells in Sjögren’s syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue" doc

... of exocrine gland [66]. In patients with pSS and recurrent or persistent swelling of the major salivary glands, the lymphocytic lesions of the involvedglands often contain massive lymphoid infiltrates ... thatmemory B cells with less migratory capacity remain in the blood as a result of the selective migration and retention of CXCR4+CXCR5+memory B cells into the inflamed glands and thereby supports ... complementarity-determining regions (HCDR3) and a less frequent usage of the sixth heavy-chain joiningsegment (JH6) [79], emphasizing the accumulation of memoryB cells. Thereby, enhanced influx and...

Báo cáo y học: "B cells in autoimmunity" ppsx

... [53,55] in myeloid cells suggests that BAFF may act as akind of secondary cytokine translating mainly IFN and TNFeffects.An important immunoregulatory cytokine produced by B cells is IL-10, which ... beeffective in human SLE. Formation of ectopic GCs has beenidentified in the kidneys of patients with SLE, in the salivaryglands of patients with Sjögren syndrome, in the thymus in patients with myasthenia ... tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade, we have expanded our understanding of effector functions of B cells...

Báo cáo Y học: Guanosine diphosphate-4-keto-6-deoxy-D-mannose reductase in the pathway for the synthesis of GDP-6-deoxy-D-talose in Actinobacillus actinomycetemcomitans potx

... report on the GDP-6-deoxy-D-talose biosynthetic pathway and the role of GDP-4-keto-6-deoxy-D-mannose reductase in the synthesis of GDP-6-deoxy-D-talose.Keywords: Actinobacillus actinomycetemcomitans;6-deoxy-talose; ... in the clusters responsible for synthesizing the SPAs in other serotypes of A. actinomycetemcomitans. The biosynthetic pathway for GDP-6-deoxy-D-talose,Fig. 5.1H NMR spectra of GTP (A) and ... undervacuumandheatedat80 °C for 1 h to hydrolyse them; theywere then dried to remove the water and HCl. The pelletswere converted into the correspondingD-(+)-2-octylglyco-side acetate by the method...

Báo cáo y học: "Subcutaneous Immunoglobulin-G Replacement Therapy with Preparations Currently Available in the United States for Intravenous or Intramuscular Use: Reasons and Regimens" docx

... the weekly dose was calculated by divid-ing the IV dose by the number of weeks in the dos-ing interval. This was then rounded off to the nearest even number of unit dose vials as the weekly ... With the exception of the two infants, the other patients selected com-binations of these variables with which they werequite happy and on which they continued treatmentfor extended periods of ... approximately 15% IgG by the addition of 40 mL of sterile water, and the resulting solution is easily contained in a 60 mLsyringe. These 10 mLand 40 mLdoses, respectively(or multiples thereof), are...

Báo cáo y học: "THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis" pps

... THR0921resulted in reduced production of TNF-α, IL-1β, and INF-γ from isolated spleen cells induced by LPS. As the involvement of each of these cytokines in the pathogenesis of arthritis is wellFigure ... derived from any of the groups (datanot shown).Cytokine expression in ankle jointsTo investigate the effect of oral administration of THR0921 at the site of joint destruction, the expression ... 3b).As inflammatory cytokines are thought to play a critical role in the pathogenesis of RA, we monitored the production of the proinfammatory cytokines TNF-α, IL-1β, and INF-γ as well asanti-inflammatory...

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