Báo cáo y học: "B cell depletion in diffuse progressive systemic sclerosis: safety, skin score modification and IL-6 modulation in an up to thirty-six months follow-up open-label trial" docx
... ARTIC LE Open Access
B cell depletion in diffuse progressive systemic
sclerosis: safety, skin score modification and IL-6
modulation in an up to thirty-six months
follow -up open-label trial
Silvia ... progressive
systemic sclerosis: safety, skin score modification and IL-6 modulation
in an up to thirty-six months foll...
...
and circulating B cells and on interleukin-6 and BAFF
(B -cell activating factor of tumor necrosis factor family).
The excellent safety pro le of rituximab in this and
other trials warrants ... cells. e clinical eff ects were paralleled by biological
eff ects, including depletion of circulating B cells, and
changes in serum levels of interleukin-6 (IL-6) and BAFF
(B...
... necrosis fac-
tor-α (TNF-α) and cytokeratin 19 were from Sigma-Aldrich
(Saint Quentin Fallavier, France). Cytokeratin 7 was from Bio-
genex (Antony, France). Cytokeratins 20 and 903, and CD45
and EnVision ...
staining for cytokeratin 7 (a) and cytokeratin 19 (b) and the absence of staining with cytokeratin 20 (c) indicates the specificity of ductal epithelial
cell origin. The a...
... multi-lobulated (hematoxylin and eosin stain;
original magnification, × 40).
Figure 1 Marked sclerosis and hyalinization in diffuse large B-
cell lymphoma (hematoxylin and eosin stain; original
magnification, ... underwent a
cervical lymph node biopsy (large excision).
According to the first biopsy findings, based on hema-
toxylin and eosin-stained slides created by co-authors...
... resulting in an inflammatory
state as well as cartilage degradation [14]. As further evi-
dence for the role of pro-inflammatory cytokines in RA,
anti-tumor necrosis factor-α (anti-TNF-α) and anti-inter-
leukin ... decreased the induction of
MMP-1 and MMP-13 by IL-1. In human primary chondrocytes,
300 nM CDDO inhibited the induction of these genes by IL-1 to
an even greater ex...
... of such cells. In cutaneous lupus erythematosus, MIG
and IP-10 have been found to be significantly upregulated in
inflamed skin and to help in the recruitment of plasmacytoid
dendritic cells (pDCs), ... of chemokine and IFN scores between SLE and RA patients, and healthy donorsComparison of chemokine and IFN scores between SLE and RA
patients, and healthy donors....
... (Peg-IFN
alpha-2a plus ribavirin) and just before starting interferon
and ribavirin therapy for chronic HCV infection, at the
Hepatology and Gastroenterology Department of the
Arnault Tzanck Institute (St Laurent ... The sensitivity and line-
arity of the assay were validated for all the genotypes [27].
Genotypes were determined by sequence and phyloge-
netic analysis of the 5'...
... grateful to Jan Lohmann and Markus Schmid for discussion, and
Wolfgang Busch, Joffrey Fitz, Stephan Ossowski, Korbinian Schneeberger,
and Norman Warthmann for helpful suggestions and critical reading ... tiling array analysis. GZ, SRH, SL,
and TS analyzed the data. TS and CKW developed online vis-
ualization tools. SL, GZ, GR, and DW wrote the manuscript.
All authors read and...
... Cooperative interaction of
nuclear factor-κB- and cis-regulatory enhancer binding pro-
tein-like factor binding elements in activating the interleukin-8
gene by pro-inflammatory cytokines. J Biol ... arthritis. Annu Rev Immunol 1996, 14:397-440.
2. Andreakos ET, Foxwell BM, Brennan FM, Maini RN, Feldmann M:
Cytokines and anti-cytokine biologicals in autoimmunity:
present and future....
... of BLyS and APRIL in a 4-hour signaling assay
by using transmembrane activator and CAML interactor (TACI)-transfected Jurkat cells and in a 4-day primary
human B -cell proliferation assay. A bead-based ... homo-
trimers, and may be present in sera in similar amounts to
APRIL and BLyS, we postulate that they may likely play
similar biologic roles to BLyS and APRIL in...