Báo cáo y học: "The loss of health status in rheumatoid arthritis and the effect of biologic therapy: a longitudinal observational study" pot
Báo cáo y học: "The loss of health status in rheumatoid arthritis and the effect of biologic therapy: a longitudinal observational study" pot
... article as: Wolfe and Michaud: The loss of health status in rheumatoid arthritis and the effect of biologic therapy: a longitudinal observational study. Arthritis Research & Therapy 2010 12:R35.Wolfe ... 0.749) Effect of biologic therapy on annual rates of progression of disability, loss of health status, and costs in patients prior to and after the start of biologic therapy in RA.All, all patients; ... be a substantial disconnectbetween damage and health status, and that pain and difficulty and uncertainty, the burden of RA, may impactmeasured self-reported health status more than damage.ConclusionsRA...
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Báo cáo y học: " What is MRI bone oedema in rheumatoid arthritis and why does it matte" ppt
... from a patient with a 1 year history of RA is shown in Figure 1.Finally, animal studies are emerging to clarify the role of the bone marrow as a site of pathology in RA. Marinova-Mutafchieva and ... oedema at the bases of the 2nd and 3rd metacarpals and adjacent regions of trapezoid and capitate carpal bones. Small intraosseous erosions are also apparent. in vascular tissue [28]. An example ... Scherer A, Modder U, Schneider M: Diagnosticvalue of magnetic resonance imaging of the forefeet in early rheumatoid arthritis when findings on imaging of the metacarpophalageal joints of the hands...
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Báo cáo y học: "Capturing real-life patient care in psoriatic arthritis and its risks: the challenge of analysing registry data" docx
... willhamper a clear adjudication of the reason for withdrawal. In summary, the study by Saad and colleagues gives usimportant insights into daily-life use of TNF inhibitors in PsA, a disease that too often ... secondary to RA in the scientific and clinical perceptions of rheumatologists. The authors dealeffectively with the challenges posed by the type and origin of their data. Although toxicity and effectiveness ... thisparadox. In RA, therapy steered by an index has becomemore and more a mainstay of management as it has beenshown that it is not the level of improvement that is decisivebut rather the disease...
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Báo cáo y học: "Gastroesophageal reflux-associated chronic cough in an adolescent and the diagnostic implications: a case report" ppt
... Hospital, 2-4-20 Ohgimachi, Kita-ku, Osaka, Japan and 3Department of Internal Medicine, Japan Baptist Hospital, 47 Yamanomoto-cho, Kitashirakawa, Sakyo-ku, Kyoto, 606-8273, JapanEmail: Makiko ... Jinnai - majin43@kuhp.kyoto-u.ac.jp; Akio Niimi* - niimi@kuhp.kyoto-u.ac.jp; Masaya Takemura - masaya.takemura@charite.de; Hisako Matsumoto - hmatsumo@kuhp.kyoto-u.ac.jp; Yoshitaka Konda - ykonda@msa.biglobe.ne.jp; ... that can detect non-acidreflux[23,24]. In any case, however, these examinationsare invasive and not widely available. As clinical clues to the diagnosis of GERD, typical symptoms such as heart-burn,...
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Báo cáo y học: "Circulating tumour necrosis factor-α bioactivity in rheumatoid arthritis patients treated with infliximab: link to clinical respone" pot
... (Biosource,Camarillo, CA, USA), in accordance with the manufac-turer's instructions.Statistical analysisStatistical analysis was performed using the Statview soft-ware (Abacus Concept Inc., Cary, ... factor (TNF) bioactivity in rheuma-toid arthritis (RA) patients and healthy individualsPattern of plasma tumour necrosis factor (TNF) bioactivity in rheuma-toid arthritis (RA) patients and healthy ... thawed before use. The main charac-teristics of the patients are summarized in Table 1.Bioassay for circulating TNF-α bioactivity A functional assay for TNF-α activity was designed usingthe...
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Báo cáo y học: "Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis" ppsx
... carbohydrate-specific anti-bodies have not yet been systematically investigated in RA, in spite of the fact that hyaline cartilage and synovial fluid containlarge amounts of GAGs including HA, ... bacterial peptidoglycans and the fungalpolysaccharide, Zymosan. Such cross-reactions may not onlyexplain the absence of anti-GAG antibodies in neonates, butmay also link infectious agents and RA.To ... only present in the systemic circulation and in the synovialfluid, but they were also fully capable of binding to the extra-cellular matrix of hyaline cartilage. Synovial fluid/serum anti-GAG...
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Báo cáo y học: "Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis" pdf
... underscored further by the findings that COMP mutationscause human skeletal dysplasia, pseudoachondroplasia(PSACH), and multiple epiphyseal dysplasia (MED) [18,19]. The clinical features of PSACH and ... phalangeal joints, metacarpal phalan-geal joints, proximal interphalangeal joints, and distal inter-phalangeal joints), and five points for a swollen ankle(maximum score per limb was 15 and maximum ... the majority of the practical work and the writing of the manuscript. The study was originallydesigned by RM, AA, ÅO, and SC in collaboration with RH.KSN helped with CAIA experiments. All authors...
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Báo cáo y học: " Multiple myeloma presenting with high-output heart failure and improving with anti-angiogenesis therapy: two case reports and a review of the literature" pdf
... injecting 99mTc-macroaggregated albuminbubbles into the femoral artery as well as the antecubitalvein, an arteriovenous shunting ratio was calculated byassessing the degree of pulmonary uptake after ... the high-output state being secondary toinnumerable intramedullary arteriovenous fistulas [1,2].If this is the case, pharmacotherapy with the ability to tar-get the underlying malignancy and ... thalidomide/dexamethasone therapy was continuedas he remained euvolemic and he was taken for a repeatcardiac catheterization two months after the initiation of therapy (Table 1). Based on his much improved clinical status, ...
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Báo cáo y học: "Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis" ppsx
... simultaneousactivation of the inflammatory response and the clottingcascade following tissue injury is a phylogenetically ancientsurvival strategy. The linkage between coagulation and inflam-mation ... Activation of cells mediated by thrombin and other coagulation factorsincreases proinflammatory cytokine synthesis and calciumflux, alters intracellular signaling cascades such as the MAPKpathway, ... tissue injury: it mechanically plugs up the physi-cal damage to the integument of the animal, and it seals off the injured area from the remainder of the crab’s open circulatorysystem. The animal...
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báo cáo hóa học: " What determines subjective health status in patients with chronic obstructive pulmonary disease: importance of symptoms in subjective health status of COPD patients" pdf
... physical health summary score is mainly based on the physical health, physical role limitations, bodily pain, and general health components, whereas the mental health summary score ismainly based ... envelopewhen they underwent the examination at the out-patientclinic. Each patient's respiratory symptoms and physical health were assessed by a physician, nurse, and physio-therapist, all specialized ... general health perception, and overall quality of life, and the impact of the characteristicson individuals and their environments. This model indi-cated that biological and physiological processes...
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