... Sugimoto1,21High Technology Research Center and 2Department of Chemistry, Faculty of Science and Engineering, Konan University,Okamoto, Higashinada–ku, Japan A clear difference in the enthalpy changes derived ... In contrast to theenthalpy and entropy changes, the free energy change and melting temperature are relatively insensitive to the heatcapacity change. Finally, the 16 NN-model free energyparameters ... thermodynamic parametersto 37 °C is completely necessary. In this case, Eqns (6) and (7) provide a reasonable and valid way to estimate thethermodynamic parameters at the temperature of interest.With...